| UniProt/SwissProt ID: | FSCN1_HUMAN |
| Description: | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) [Source:HGNC Symbol;Acc:11148] |
| Location: | chr7 p22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T484 | KASAEtVDPAS | Fascin | PhosphoSitePlus |
| Y145 | PQVNIySVTRK | Fascin | PhosphoSitePlus |
| S39 | NASASsLKKKQ | PKC_group | phosphoELM; RegPhos |
| T148 | NIYSVtRKRYA | Fascin | PhosphoSitePlus |
| S120 | TEDRLsCFAQT | Fascin | PhosphoSitePlus |
| S39 | NASASsLKKKQ | PKCd | RegPhos |
| Y23 | NCGNKyLTAEA | Fascin | PhosphoSitePlus |
| S39 | NASASsLKKKQ | PRKCD | HPRD |
| S39 | NASASsLKKKQ | phosphoELM | |
| S38 | VNASAsSLKKK | HPRD; phosphoELM; SysPTM | |
| S39 | NASASsLKKKQ | Fascin | PhosphoSitePlus |
| Y314 | THTGKyWTLTA | Fascin | PhosphoSitePlus |
| S38 | VNASAsSLKKK | Fascin | PhosphoSitePlus; SysPTM |
| T239 | SGPSGtLKAGK | Fascin | PhosphoSitePlus |
| Dephosphorylation site |
| FSCN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000371798 | V323M | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| FSCN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S39 | Fascin | KVNASASsLKKKQIW | cancer, squamous cell carcinoma | 20713986 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCD_HUMAN | FSCN1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| FSCN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030175 | filopodium | IEA | cellular_component |
| GO:0030036 | actin cytoskeleton organization | IDA | biological_process |
| GO:0008144 | drug binding | IEA | molecular_function |
| GO:0051017 | actin filament bundle assembly | IEA | biological_process |
| GO:0071437 | invadopodium | IDA | cellular_component |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0001725 | stress fiber | IDA | cellular_component |
| GO:0016477 | cell migration | IEA | biological_process |
| GO:0030674 | protein binding, bridging | IEA | molecular_function |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0048870 | cell motility | IDA | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0051015 | actin filament binding | IEA | molecular_function |
| GO:0003779 | actin binding | IDA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |