Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FLT3_HUMAN
Description:fms-related tyrosine kinase 3 [Source:HGNC Symbol;Acc:3765]
Location:chr13 q12.2
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y842MSDSNyVVRGNphosphoELM; RegPhos
Y793LLCFAyQVAKGPkinase_TyrPhosphoSitePlus
Y591DNEYFyVDFREFLT3HPRD; phosphoELM; RegPhos
S993AQVEDs_____PhosphoSitePlus
Y589SSDNEyFYVDFFLT3HPRD; phosphoELM; RegPhos
Y842MSDSNyVVRGNPkinase_TyrPhosphoSitePlus
Y166RNTLLyTLRRPPhosphoSitePlus
Y416HQPGEyIFHAEPhosphoSitePlus
Y597VDFREyEYDLKFLT3HPRD; phosphoELM; RegPhos
S759GLHGNsFHSEDPkinase_TyrPhosphoSitePlus
Y955AEEAMyQNVDGPhosphoSitePlus
Y597VDFREyEYDLKPhosphoSitePlus
Y599FREYEyDLKWEPhosphoSitePlus
Y969ECPHTyQNRRPPhosphoSitePlus
Y630MNATAyGISKTPkinase_TyrPhosphoSitePlus
Y591DNEYFyVDFREPhosphoSitePlus
Y726HNFSFyPTFQSPkinase_TyrPhosphoSitePlus
Y589SSDNEyFYVDFPhosphoSitePlus
T728FSFYPtFQSHPPkinase_TyrPhosphoSitePlus
T343QSALVtIVEKGPhosphoSitePlus
Y572KKQFRyESQLQPhosphoSitePlus
S840DIMSDsNYVVRPkinase_TyrPhosphoSitePlus
Y599FREYEyDLKWEFLT3HPRD; phosphoELM; RegPhos
T968SECPHtYQNRRPhosphoSitePlus
Y768EDEIEyENQKRPkinase_TyrPhosphoSitePlus

Dephosphorylation site
FLT3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000241453A953VCOSMICOvarian Cancer20668451
ENSP00000241453D835YHPIacute lymphocytic leukemia11442493 11290608 14504097 20924716
ENSP00000241453M737ICOSMICLymphoma18068628
ENSP00000241453G831ECOSMICLymphoma
ENSP00000241453C563SCOSMICLymphoma17056111
ENSP00000241453A680VCOSMICLymphoma14554237
ENSP00000241453R834QCOSMICLymphoma18068628
ENSP00000241453I836delCOSMICLymphoma22072526
ENSP00000241453Y842CCOSMICLymphoma15345593
ENSP00000241453Q575PCOSMICLymphoma21909114
ENSP00000241453D895NCOSMICLung Cancer20668451
ENSP00000241453P986SCOSMICSkin Cancer21984974
ENSP00000241453I836MHPIacute lymphocytic leukemia14504097
ENSP00000241453T167ACOSMICLymphoma18068628
ENSP00000241453V491LCOSMICOvarian Cancer21720365
ENSP00000241453E598GCOSMICLymphoma17056111
ENSP00000241453H761PCOSMICSkin Cancer21984974
ENSP00000241453V557ICOSMICLymphoma18068628
ENSP00000241453N841KCOSMICLymphoma15625552
ENSP00000241453S519YCOSMICSkin Cancer21984974
ENSP00000241453V615ACOSMICOvarian Cancer21720365
ENSP00000241453P31LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000241453A627TCOSMICLymphoma17088437
ENSP00000241453D835HCOSMICLymphoma14737077
ENSP00000241453D835YOMIMLeukemia11290608 11442493 14670924
ENSP00000241453S574GCOSMICLymphoma17056111
ENSP00000241453E964KCOSMICMelanoma21499247
ENSP00000241453Y599FCOSMICLymphoma17330105
ENSP00000241453V194MCOSMICGastric Cancer21097718
ENSP00000241453V592ACOSMICLymphoma
ENSP00000241453Q577PCOSMICLung Cancer20668451
ENSP00000241453S451FCOSMICLymphoma18068628
ENSP00000241453Y572CCOSMICLymphoma18664261
ENSP00000241453V579ACOSMICLymphoma14984498
ENSP00000241453S670RCOSMICLung Cancer20668451
ENSP00000241453L947PCOSMICLung Cancer20668451
ENSP00000241453F594ICOSMICLymphoma20924583
ENSP00000241453I836SCOSMICLymphoma14737077
ENSP00000241453S930*COSMICLung Cancer20668451
ENSP00000241453N530YCOSMICLymphoma17056111
ENSP00000241453K663QCOSMICLymphoma16990784
ENSP00000241453Y364HCOSMICLymphoma18068628
ENSP00000241453D324NCOSMICLymphoma19657110
ENSP00000241453Y591CCOSMICLymphoma16410449

Differential expressed protein
FLT3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FLT3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FLT3L_HUMANFLT3_HUMANligand -> receptorHPMR
FLT3_HUMANFLT3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANFLT3_HUMANkinase -> substrateRegPhos
FLT3_HUMANSHC1_HUMANkinase -> substrateRegPhos
FLT3L_HUMANFLT3_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04640Hematopoietic cell lineage
hsa05221Acute myeloid leukemia
hsa04060Cytokine-cytokine receptor interaction
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030097hemopoiesisIDAbiological_process
GO:0043410positive regulation of MAPK cascadeTASbiological_process
GO:0097028dendritic cell differentiationISSbiological_process
GO:0005021vascular endothelial growth factor-activated recepTASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030183B cell differentiationISSbiological_process
GO:0045578negative regulation of B cell differentiationIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0042981regulation of apoptotic processTASbiological_process
GO:0002320lymphoid progenitor cell differentiationIEAbiological_process
GO:0005788endoplasmic reticulum lumenIEAcellular_component
GO:0035726common myeloid progenitor cell proliferationISSbiological_process
GO:0002318myeloid progenitor cell differentiationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001776leukocyte homeostasisISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0071345cellular response to cytokine stimulusISSbiological_process
GO:0043406positive regulation of MAP kinase activityTASbiological_process
GO:0042531positive regulation of tyrosine phosphorylation ofTASbiological_process
GO:0002318myeloid progenitor cell differentiationISSbiological_process
GO:0002328pro-B cell differentiationISSbiological_process
GO:0019221cytokine-mediated signaling pathwayISSbiological_process
GO:0030098lymphocyte differentiationIEAbiological_process
GO:0002328pro-B cell differentiationIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0046651lymphocyte proliferationISSbiological_process
GO:0046777protein autophosphorylationTASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0042803protein homodimerization activityTASmolecular_function
GO:0002572pro-T cell differentiationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0038084vascular endothelial growth factor signaling pathwTASbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0004896cytokine receptor activityISSmolecular_function