| UniProt/SwissProt ID: | FIP1_HUMAN |
| Description: | FIP1 like 1 (S. cerevisiae) [Source:HGNC Symbol;Acc:19124] |
| Location: | chr4 q12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y27 | EEEWLyGGPWD | PhosphoSitePlus | |
| S443 | APSWPsLVDTS | PhosphoSitePlus | |
| T588 | PEQEStEATP | HPRD | |
| S274 | PPSRNsTSSQS | PhosphoSitePlus | |
| T283 | QSQTStASRKA | PhosphoSitePlus | |
| Y510 | YRYREyAERGY | PhosphoSitePlus | |
| Y110 | TGAPQyGSYGT | PhosphoSitePlus; phosphoELM | |
| T494 | RDHSPtPSVFN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S559 | SEEGDsHRRHK | PhosphoSitePlus; HPRD | |
| S440 | PGSAPsWPSLV | PhosphoSitePlus | |
| S14 | LVSELsGGTGG | HPRD | |
| T482 | RERERtRERER | PhosphoSitePlus; HPRD | |
| Y505 | SDEERyRYREY | PhosphoSitePlus; HPRD | |
| S554 | RRRHEsEEGDS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T221 | CTMEVtPGAEI | PhosphoSitePlus | |
| S579 | GKEAGsEPAPE | PhosphoSitePlus; HPRD | |
| S262 | FTSPPsLFKTG | HPRD | |
| S85 | ETEDDsDSDSD | PhosphoSitePlus; HPRD; phosphoELM | |
| S277 | RNSTSsQSQTS | PhosphoSitePlus | |
| S587 | APEQEsTEATP | HPRD | |
| T591 | ESTEAtPAE__ | PhosphoSitePlus | |
| S548 | SSRSNsRRRHE | PhosphoSitePlus; HPRD | |
| S89 | DSDSDsDDDED | PhosphoSitePlus; HPRD; phosphoELM | |
| Y113 | PQYGSyGTAPV | PhosphoSitePlus; phosphoELM | |
| S112 | APQYGsYGTAP | PhosphoSitePlus | |
| T281 | SSQSQtSTASR | PhosphoSitePlus | |
| Y454 | KQWDYyARREK | PhosphoSitePlus | |
| Y453 | SKQWDyYARRE | PhosphoSitePlus | |
| S259 | KAEFTsPPSLF | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T81 | PKVTEtEDDSD | HPRD; phosphoELM | |
| T99 | DDVHVtIGDIK | HPRD | |
| S304 | YGRAEsPDLRR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y515 | YAERGyERHRA | PhosphoSitePlus | |
| Y175 | ADLSDyFNYGF | Fip1 | PhosphoSitePlus |
| Y129 | TGGRVyGTTGT | PhosphoSitePlus | |
| S492 | RERDHsPTPSV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T79 | PKPKVtETEDD | HPRD; phosphoELM | |
| Y426 | ARAFPyGNVAF | PhosphoSitePlus; phosphoELM | |
| Y299 | KWQDRyGRAES | HPRD | |
| S496 | HSPTPsVFNSD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S279 | STSSQsQTSTA | PhosphoSitePlus | |
| S37 | DVHVHsDLAKD | PhosphoSitePlus | |
| S87 | EDDSDsDSDDD | PhosphoSitePlus; HPRD; phosphoELM | |
| S500 | PSVFNsDEERY | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| FIP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000336752 | W165R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000336752 | E45G | COSMIC | Hepatocellular Carcinoma | 21822264 | ENSP00000336752 | V6I | COSMIC | Melanoma |
| Differential expressed protein |
| FIP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FIP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | FIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SGK3_HUMAN | FIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | FIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | FIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FIP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005847 | mRNA cleavage and polyadenylation specificity fact | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004714 | transmembrane receptor protein tyrosine kinase act | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |