| UniProt/SwissProt ID: | FBX3_HUMAN |
| Description: | F-box protein 3 [Source:HGNC Symbol;Acc:13582] |
| Location: | chr11 p13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y223 | KNEVFyQCPDQ | SMI1_KNR4 | PhosphoSitePlus |
| Y420 | MGPDEyEEMEE | PhosphoSitePlus | |
| S166 | GSMALsNHYRS | SMI1_KNR4 | PhosphoSitePlus |
| Dephosphorylation site |
| FBX3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000408836 | S287L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265651 | S287L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265651 | V177I | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| FBX3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FBX3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | FBX3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FBX3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004842 | ubiquitin-protein ligase activity | TAS | molecular_function |
| GO:0006508 | proteolysis | TAS | biological_process |
| GO:0016567 | protein ubiquitination | TAS | biological_process |