| UniProt/SwissProt ID: | FBRL_HUMAN |
| Description: | fibrillarin [Source:HGNC Symbol;Acc:3599] |
| Location: | chr19 q13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S126 | KRVSIsEGDDK | HPRD | |
| S124 | GEKRVsISEGD | Fibrillarin | PhosphoSitePlus |
| T208 | LAKKRtNIIPV | HPRD | |
| T208 | LAKKRtNIIPV | Fibrillarin | PhosphoSitePlus |
| S124 | GEKRVsISEGD | HPRD; phosphoELM | |
| Y118 | PGESVyGEKRV | Fibrillarin | PhosphoSitePlus |
| S116 | LVPGEsVYGEK | Fibrillarin | PhosphoSitePlus |
| Y302 | LTLEPyERDHA | Fibrillarin | PhosphoSitePlus |
| S126 | KRVSIsEGDDK | Fibrillarin | PhosphoSitePlus |
| T298 | PQEQLtLEPYE | Fibrillarin | PhosphoSitePlus |
| Dephosphorylation site |
| FBRL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000221801 | G47V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000221801 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.5 | 20739354 |
| Hyperphosphorylation site |
| FBRL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK08_HUMAN | FBRL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FBRL_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006396 | RNA processing | IEA | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0008168 | methyltransferase activity | IEA | molecular_function |
| GO:0001652 | granular component | IEA | cellular_component |
| GO:0008033 | tRNA processing | IEA | biological_process |
| GO:0006364 | rRNA processing | IEA | biological_process |
| GO:0016074 | snoRNA metabolic process | IEA | biological_process |
| GO:0015030 | Cajal body | IDA | cellular_component |
| GO:0031428 | box C/D snoRNP complex | NAS | cellular_component |
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0001651 | dense fibrillar component | IEA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0015030 | Cajal body | IEA | cellular_component |