| UniProt/SwissProt ID: | FASTK_HUMAN |
| Description: | Fas-activated serine/threonine kinase [Source:HGNC Symbol;Acc:24676] |
| Location: | chr7 q36.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S94 | LEQAKsPGELL | PhosphoSitePlus | |
| Y532 | PQLKSyLRQKL | PhosphoSitePlus | |
| Dephosphorylation site |
| FASTK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000297532 | V424L | HPI | Lung Cancer | 17344846 |
| Differential expressed protein |
| FASTK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FASTK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FASTK_HUMAN | TIA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FASTK_HUMAN | PITX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FASTK_HUMAN | CBL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FASTK_HUMAN | STF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FASTK_HUMAN | CRY1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FASTK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0033867 | Fas-activated serine/threonine kinase activity | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0043484 | regulation of RNA splicing | IDA | biological_process |
| GO:0097190 | apoptotic signaling pathway | TAS | biological_process |