| UniProt/SwissProt ID: | FANCC_HUMAN |
| Description: | Fanconi anemia, complementation group C [Source:HGNC Symbol;Acc:3584] |
| Location: | chr9 q22.32 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S57 | LKEMDsNTVIE | Fanconi_C | PhosphoSitePlus |
| Dephosphorylation site |
| FANCC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364454 | E539K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289081 | W533* | COSMIC | Skin Cancer | 21984974 | ENSP00000289081 | E539K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289081 | L450M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000289081 | C96F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000289081 | T319R | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| FANCC_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FANCC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | FANCC_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| FANCC_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006461 | protein complex assembly | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0006289 | nucleotide-excision repair | IEA | biological_process |
| GO:0007281 | germ cell development | IEA | biological_process |
| GO:0043240 | Fanconi anaemia nuclear complex | IDA | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0019430 | removal of superoxide radicals | IEA | biological_process |
| GO:0002262 | myeloid cell homeostasis | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0007276 | gamete generation | IEA | biological_process |