| UniProt/SwissProt ID: | FAF1_HUMAN |
| Description: | Fas (TNFRSF6) associated factor 1 [Source:HGNC Symbol;Acc:3578] |
| Location: | chr1 p32.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S270 | VGRRSsPAQTR | PhosphoSitePlus; HPRD | |
| S289 | DVHMVsDSDGD | CK2a1-rs | RegPhos |
| S342 | FTAEFsSRYGD | PhosphoSitePlus | |
| S291 | HMVSDsDGDDF | CK2_group | phosphoELM; RegPhos |
| S289 | DVHMVsDSDGD | CK2_group | phosphoELM; RegPhos |
| S291 | HMVSDsDGDDF | CK2a1 | RegPhos |
| Y225 | VKRNVyDLTSI | HPRD; RegPhos | |
| Y225 | VKRNVyDLTSI | ubiquitin | PhosphoSitePlus |
| S291 | HMVSDsDGDDF | CK2a1(CK2 alpha | RegPhos |
| S291 | HMVSDsDGDDF | CK2a1-rs | RegPhos |
| S320 | SALRKsPMMPE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S582 | RIRTPsGEFLE | UBX | PhosphoSitePlus |
| S153 | GDVEDsTVLKS | HPRD | |
| S291 | HMVSDsDGDDF | CK2_alpha | phosphoELM |
| S289 | DVHMVsDSDGD | CK2a1 | RegPhos |
| S343 | TAEFSsRYGDC | PhosphoSitePlus | |
| T580 | KLRIRtPSGEF | UBX | PhosphoSitePlus |
| S289 | DVHMVsDSDGD | CSNK2A1 | HPRD |
| S582 | RIRTPsGEFLE | HPRD | |
| T274 | SSPAQtREQSE | PhosphoSitePlus; HPRD | |
| S291 | HMVSDsDGDDF | CSNK2A1 | HPRD |
| S289 | DVHMVsDSDGD | PhosphoSitePlus | |
| S291 | HMVSDsDGDDF | PhosphoSitePlus | |
| S289 | DVHMVsDSDGD | CK2_alpha | phosphoELM |
| S289 | DVHMVsDSDGD | CK2a1(CK2 alpha | RegPhos |
| Dephosphorylation site |
| FAF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379457 | P89S | COSMIC | Pancreatic Cancer | ENSP00000360843 | P89S | COSMIC | Pancreatic Cancer | ENSP00000379457 | F602S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000360843 | F602S | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| FAF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FAF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | FAF1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | FAF1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| FAF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051059 | NF-kappaB binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | NAS | biological_process |
| GO:0031072 | heat shock protein binding | IDA | molecular_function |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |
| GO:0008219 | cell death | IMP | biological_process |
| GO:0031334 | positive regulation of protein complex assembly | IMP | biological_process |
| GO:0042176 | regulation of protein catabolic process | IMP | biological_process |
| GO:0019901 | protein kinase binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0045859 | regulation of protein kinase activity | NAS | biological_process |
| GO:0043130 | ubiquitin binding | IDA | molecular_function |
| GO:0031625 | ubiquitin protein ligase binding | IDA | molecular_function |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0005635 | nuclear envelope | IEA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007253 | cytoplasmic sequestering of NF-kappaB | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030155 | regulation of cell adhesion | IEA | biological_process |
| GO:0034098 | Cdc48p-Npl4p-Ufd1p AAA ATPase complex | IDA | cellular_component |
| GO:0031265 | CD95 death-inducing signaling complex | NAS | cellular_component |
| GO:0019904 | protein domain specific binding | IEA | molecular_function |
| GO:0019887 | protein kinase regulator activity | NAS | molecular_function |
| GO:0043065 | positive regulation of apoptotic process | NAS | biological_process |