Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERBB2_HUMAN
Description:v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [Source:HGNC Symbol;Acc:3430]
Location:chr17 q12
Node attribute:substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1248AENPEyLGLDVErbB2phosphoELM; RegPhos; SysPTM
S1066LGLEPsEEEAPPhosphoSitePlus
T701LVEPLtPSGAMDUF4381PhosphoSitePlus
S1054SSSTRsGGGDLPhosphoSitePlus; phosphoELM; SysPTM
T1236GAPPStFKGTPPhosphoSitePlus
T1198NPEYLtPQGGAPhosphoSitePlus
T1240STFKGtPTAENPhosphoSitePlus
S1107PTHDPsPLQRYPhosphoSitePlus
T686KIRKYtMRRLLDUF4381PhosphoSitePlus
S1051RHRSSsTRSGGPhosphoSitePlus
S1007STFYRsLLEDDPhosphoSitePlus
Y1196VENPEyLTPQGPhosphoSitePlus; RegPhos
Y1112SPLQRySEDPTPhosphoSitePlus; phosphoELM; RegPhos
S1214PPPAFsPAFDNPhosphoSitePlus
Y1222FDNLYyWDQDPErbB2phosphoELM; RegPhos
Y1248AENPEyLGLDVautocatalysis RegPhos; SysPTM
Y1127SETDGyVAPLTPhosphoSitePlus
S998DLGPAsPLDSTPhosphoSitePlus
Y877IDETEyHADGGphosphoELM; RegPhos
S1002ASPLDsTFYRSPhosphoSitePlus
Y772ILDEAyVMAGVPkinase_TyrPhosphoSitePlus
S1050HRHRSsSTRSGPhosphoSitePlus
S1235RGAPPsTFKGTPhosphoSitePlus
T1052HRSSStRSGGGPhosphoSitePlus
T1172LERPKtLSPGKPhosphoSitePlus
T733SGAFGtVYKGIPkinase_TyrPhosphoSitePlus
Y1139SPQPEyVNQPDPhosphoSitePlus
S1134APLTCsPQPEYPhosphoSitePlus; phosphoELM
T1172LERPKtLSPGKCaMK2aRegPhos
S1151RPQPPsPREGPPhosphoSitePlus; phosphoELM
Y1196VENPEyLTPQGErbB2phosphoELM; RegPhos
Y1023VDAEEyLVPQQPhosphoSitePlus
Y735AFGTVyKGIWIphosphoELM
Y1005LDSTFyRSLLEPhosphoSitePlus
S728VKVLGsGAFGTPkinase_TyrPhosphoSitePlus
T1132YVAPLtCSPQPPhosphoSitePlus
T1172LERPKtLSPGKCaM-KII_alphaphosphoELM
Y1248AENPEyLGLDVEGFRRegPhos; SysPTM
Y1139SPQPEyVNQPDautocatalysis RegPhos
T875LDIDEtEYHADPkinase_TyrPhosphoSitePlus
Y1221AFDNLyYWDQDPhosphoSitePlus
Y1023VDAEEyLVPQQErbB2RegPhos
S1049HHRHRsSSTRSPhosphoSitePlus
T948QPPICtIDVYMPkinase_TyrPhosphoSitePlus
S703EPLTPsGAMPNDUF4381PhosphoSitePlus
Y1139SPQPEyVNQPDErbB2phosphoELM; RegPhos
Y877IDETEyHADGGPkinase_TyrPhosphoSitePlus
Y1221AFDNLyYWDQDErbB2phosphoELM; RegPhos
T1124PLPSEtDGYVAPhosphoSitePlus
T686KIRKYtMRRLLphosphoELM; RegPhos
Y1248AENPEyLGLDVPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
T1166RPAGAtLERPKPhosphoSitePlus
Y735AFGTVyKGIWIPkinase_TyrPhosphoSitePlus
S1122TVPLPsETDGYPhosphoSitePlus
Y1222FDNLYyWDQDPPhosphoSitePlus

Dephosphorylation site
ERBB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000269571S310FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000269571E914KOMIM, HPINeoplasms by Histologic Type15457249
ENSP00000269571W906*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000269571G776SGreenman2007, HPI, OMIMGastric Cancer15457249, 17344846, 18428421, 15457249, 17344846, 15457249 17344846
ENSP00000269571L755POMIM, HPILung Cancer15457249
ENSP00000269571N857SOMIM, HPIOvarian Cancer15457249, 15457249 17344846

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000269571Breast CancerNormal vs. Cancercell lineUp6.920198662

Hyperphosphorylation site
ERBB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRG1_HUMANERBB2_HUMANligand -> receptorHPMR
ERBB2_HUMANEGFR_HUMANkinase -> substrateHPRD
ERBB2_HUMANERBB2_HUMANkinase -> substrateNetPath
SRC_HUMANERBB2_HUMANkinase -> substrateNetPath
ZAGL2_HUMANERBB2_HUMANkinase -> substrateRegPhos
EGFR_HUMANERBB2_HUMANkinase -> substrateHPRD; RegPhos
PPAP_HUMANERBB2_HUMANphosphatase -> substrateHPRD
MYC_HUMANERBB2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
hsa05223Non-small cell lung cancer
hsa05213Endometrial cancer
hsa04012ErbB signaling pathway
hsa05215Prostate cancer
hsa04520Adherens junction
hsa04020Calcium signaling pathway
hsa05219Bladder cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneNAScellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0001042RNA polymerase I core bindingIDAmolecular_function
GO:0010008endosome membraneIDAcellular_component
GO:0007528neuromuscular junction developmentIEAbiological_process
GO:0004713protein tyrosine kinase activityIDAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0045943positive regulation of transcription from RNA polyIMPbiological_process
GO:0046983protein dimerization activityNASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0008283cell proliferationTASbiological_process
GO:0045785positive regulation of cell adhesionIDAbiological_process
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0023014signal transduction by phosphorylationTASbiological_process
GO:0005006epidermal growth factor-activated receptor activitNASmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0032321positive regulation of Rho GTPase activityIEAbiological_process
GO:0019838growth factor bindingIDAmolecular_function
GO:0007165signal transductionIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030879mammary gland developmentTASbiological_process
GO:0004888transmembrane signaling receptor activityIDAmolecular_function
GO:0045765regulation of angiogenesisNASbiological_process
GO:0016324apical plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0032886regulation of microtubule-based processIDAbiological_process
GO:0008045motor neuron axon guidanceIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0030307positive regulation of cell growthIMPbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0007507heart developmentIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0043125ErbB-3 class receptor bindingTASmolecular_function
GO:0042552myelinationIEAbiological_process
GO:0045727positive regulation of translationIMPbiological_process
GO:0007166cell surface receptor signaling pathwayIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0042060wound healingIDAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIDAbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitIEAmolecular_function
GO:0045945positive regulation of transcription from RNA polyIDAbiological_process
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0007167enzyme linked receptor protein signaling pathwayTASbiological_process
GO:0033088negative regulation of immature T cell proliferatiIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0043235receptor complexIDAcellular_component
GO:0007173epidermal growth factor receptor signaling pathwayNASbiological_process
GO:0004672protein kinase activityIEAmolecular_function