Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA8_HUMAN
Description:EPH receptor A8 [Source:HGNC Symbol;Acc:3391]
Location:chr1 p36.12
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S177SVGPLsKRGFYEphrin_lbdPhosphoSitePlus
T704LEGVVtRGRLAPkinase_TyrPhosphoSitePlus
T498VTTRAtVSGLKfn3; PhoDPhosphoSitePlus
S782SDFGLsRVLEDPkinase_TyrPhosphoSitePlus
Y478YEIKYyEKDKEfn3PhosphoSitePlus
S457GQTSVsLLWQEfn3PhosphoSitePlus
Y839YGERPyWNMTNautocatalysis RegPhos
S909ATATVsRCPPPPhosphoSitePlus
Y793DPDAAyTTTGGPkinase_TyrPhosphoSitePlus
Y616AEPHTyEEPGREphA8phosphoELM; RegPhos
Y839YGERPyWNMTNEPHA8HPRD
Y616AEPHTyEEPGREPHA8HPRD
Y839YGERPyWNMTNEphA8phosphoELM; RegPhos
S224TGADSsSLVEVPhosphoSitePlus
T454ERAGQtSVSLLfn3PhosphoSitePlus
S225GADSSsLVEVRPhosphoSitePlus
Y715MIVTEyMENGSPkinase_TyrPhosphoSitePlus
Y616AEPHTyEEPGRautocatalysis RegPhos
T905ESLRAtATVSRPhosphoSitePlus
T907LRATAtVSRCPPhosphoSitePlus
S455RAGQTsVSLLWfn3PhosphoSitePlus

Dephosphorylation site
EPHA8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000166244P860LGreenman2007Skin Cancer17344846, 18428421
ENSP00000363775R367CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000440274R367CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000166244N123KHPIbreast ductal carcinoma17344846
ENSP00000166244R179CGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000166244R198LGreenman2007, HPILung Cancer17344846, 18428421
ENSP00000166244N123KGreenman2007Breast Cancer17344846, 18428421
ENSP00000363775L492FCOSMICGastric Cancer21097718

Differential expressed protein
EPHA8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPHA8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA3_HUMANEPHA8_HUMANligand -> receptorHPMR
EFNA5_HUMANEPHA8_HUMANligand -> receptorHPMR
EFNA2_HUMANEPHA8_HUMANligand -> receptorHPMR
EPHA8_HUMANEPHA8_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030155regulation of cell adhesionISSbiological_process
GO:0033628regulation of cell adhesion mediated by integrinIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0006929substrate-dependent cell migrationISSbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0031175neuron projection developmentISSbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0016322neuron remodelingIEAbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0016322neuron remodelingISSbiological_process
GO:0033628regulation of cell adhesion mediated by integrinISSbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0048013ephrin receptor signaling pathwayISSbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0043410positive regulation of MAPK cascadeISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006929substrate-dependent cell migrationIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0005004GPI-linked ephrin receptor activityISSmolecular_function
GO:0043005neuron projectionISScellular_component
GO:0005004GPI-linked ephrin receptor activityIEAmolecular_function


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