Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA4_HUMAN
Description:EPH receptor A4 [Source:HGNC Symbol;Acc:3388]
Location:chr2 q36.1
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S741YLSDMsYVHRDPkinase_TyrPhosphoSitePlus
Y602VDPFTyEDPNQEPHA4HPRD
T354SSPQNtGGRQDSusE; fn3PhosphoSitePlus
Y602VDPFTyEDPNQPhosphoSitePlus
Y602VDPFTyEDPNQEphA4phosphoELM; RegPhos
S350NLEWSsPQNTGSusE; fn3PhosphoSitePlus
S637FGEVCsGRLKVPkinase_TyrPhosphoSitePlus
T117PGVMGtCKETFEphrin_lbdPhosphoSitePlus
Y779DPEAAyTTRGGPkinase_TyrPhosphoSitePlus
T957ARIGItAITHQSAM_2PhosphoSitePlus
Y596QGVRTyVDPFTEPHA4HPRD
T595NQGVRtYVDPFCD34_antigenPhosphoSitePlus
Y596QGVRTyVDPFTCD34_antigenPhosphoSitePlus
Y596QGVRTyVDPFTEphA4phosphoELM; RegPhos
Y928IKMDRyKDNFTautocatalysis RegPhos
T781EAAYTtRGGKIPkinase_TyrPhosphoSitePlus
Y779DPEAAyTTRGGautocatalysis RegPhos
Y798PEAIAyRKFTSPkinase_TyrPhosphoSitePlus
S349VNLEWsSPQNTSusE; fn3PhosphoSitePlus
T168IMKLNtEIRDVEphrin_lbdPhosphoSitePlus
Y602VDPFTyEDPNQautocatalysis RegPhos
Y779DPEAAyTTRGGphosphoELM
Y596QGVRTyVDPFTautocatalysis RegPhos

Dephosphorylation site
EPHA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000281821S399FGreenman2007Skin Cancer17344846, 18428421
ENSP00000386829G370EGreenman2007, HPIUrinary Bladder Cancer17344846, 18428421
ENSP00000281821Q948XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000386829G370EGreenman2007Other Cancer(urinary_tract cancer)17344846, 18428421
ENSP00000281821G41ECOSMICHead and Neck Cancer21798893
ENSP00000281821R538QCOSMICHead and Neck Cancer21798893
ENSP00000386829S399FGreenman2007Skin Cancer17344846, 18428421
ENSP00000386829E670DDing2008Lung Cancer18948947
ENSP00000281821E670DDing2008Lung Cancer18948947
ENSP00000281821G370EGreenman2007, HPIUrinary Bladder Cancer17344846, 18428421
ENSP00000281821G370EGreenman2007Other Cancer(urinary_tract cancer)17344846, 18428421

Differential expressed protein
EPHA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPHA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA3_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNA5_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNA2_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNB2_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNB3_HUMANEPHA4_HUMANligand -> receptorHPMR
EFNA1_HUMANEPHA4_HUMANligand -> receptorHPMR
EPHA4_HUMANEPHA4_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045211postsynaptic membraneIEAcellular_component
GO:0031901early endosome membraneIEAcellular_component
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0030425dendriteISScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0044295axonal growth coneIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0097156fasciculation of motor neuron axonIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0005004GPI-linked ephrin receptor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:2001108positive regulation of Rho guanyl-nucleotide exchaIDAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0007628adult walking behaviorIEAbiological_process
GO:0030175filopodiumIEAcellular_component
GO:0007155cell adhesionIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0046777protein autophosphorylationIDAbiological_process
GO:0042731PH domain bindingIPImolecular_function
GO:0030054cell junctionIEAcellular_component
GO:0021957corticospinal tract morphogenesisIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0032319regulation of Rho GTPase activityIEAbiological_process
GO:0005005transmembrane-ephrin receptor activityIEAmolecular_function
GO:0042995cell projectionIEAcellular_component
GO:0032317regulation of Rap GTPase activityIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008347glial cell migrationIEAbiological_process
GO:0048681negative regulation of axon regenerationIEAbiological_process
GO:0032314regulation of Rac GTPase activityIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0043204perikaryonIEAcellular_component
GO:0005887integral to plasma membraneIEAcellular_component
GO:0061001regulation of dendritic spine morphogenesisIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0050770regulation of axonogenesisIEAbiological_process
GO:0048710regulation of astrocyte differentiationIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0097155fasciculation of sensory neuron axonIEAbiological_process
GO:0043507positive regulation of JUN kinase activityIEAbiological_process
GO:0097161DH domain bindingIDAmolecular_function
GO:0050775positive regulation of dendrite morphogenesisIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030424axonISScellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0043197dendritic spineIEAcellular_component
GO:0050770regulation of axonogenesisISSbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0008045motor neuron axon guidanceIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0005737cytoplasmISScellular_component


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