Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA2_HUMAN
Description:EPH receptor A2 [Source:HGNC Symbol;Acc:3386]
Location:chr1 p36.13
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T587LKPLKtYVDPHPhosphoSitePlus; HPRD
Y960QKRIAySLLGLHPRD; SysPTM
Y921IKMQQyTEHFMHPRD; phosphoELM; SysPTM
T593YVDPHtYEDPNPhosphoSitePlus; HPRD
T940KVVQMtNDDIKSAM_1PhosphoSitePlus
T898IRLPStSGSEGEPHA2HPRD; SysPTM
T771DDPEAtYTTSGPkinase_TyrPhosphoSitePlus
S892FDPRVsIRLPSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y791PEAISyRKFTSPkinase_TyrPhosphoSitePlus
T773PEATYtTSGGKPkinase_TyrPhosphoSitePlus; SysPTM
T773PEATYtTSGGKHPRD; SysPTM
S961KRIAYsLLGLKSAM_1PhosphoSitePlus
Y588KPLKTyVDPHTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y67MPIYMySVCNVEphrin_lbdPhosphoSitePlus
S426LVTSRsFRTASPhosphoSitePlus
T771DDPEAtYTTSGHPRD
T437VSINQtEPPKVfn3PhosphoSitePlus
S577EDVYFsKSEQLPhosphoSitePlus
Y921IKMQQyTEHFMSAM_1PhosphoSitePlus; SysPTM
S756LVCKVsDFGLSPkinase_TyrPhosphoSitePlus
S579VYFSKsEQLKPPhosphoSitePlus; HPRD; SysPTM
S749NILVNsNLVCKPkinase_TyrPhosphoSitePlus
Y930FMAAGyTAIEKSAM_1PhosphoSitePlus
S433RTASVsINQTEPhosphoSitePlus
S901PSTSGsEGVPFEPHA2HPRD; SysPTM
Y735LANMNyVHRDLPkinase_TyrPhosphoSitePlus
Y694MIITEyMENGAPkinase_TyrPhosphoSitePlus
T692PMMIItEYMENPkinase_TyrPhosphoSitePlus
Y772DPEATyTTSGGPkinase_TyrPhosphoSitePlus; SysPTM
S897SIRLPsTSGSEEPHA2HPRD; SysPTM
S880IRAPDsLKTLAPhosphoSitePlus
Y628EFGEVyKGMLKHPRD; SysPTM
S897SIRLPsTSGSEPhosphoSitePlus; phosphoELM; SysPTM
Y772DPEATyTTSGGHPRD; phosphoELM; SysPTM
Y628EFGEVyKGMLKPkinase_TyrPhosphoSitePlus; SysPTM
S899RLPSTsGSEGVEPHA2HPRD; SysPTM
Y960QKRIAySLLGLSAM_1PhosphoSitePlus; SysPTM
S901PSTSGsEGVPFPhosphoSitePlus; phosphoELM; SysPTM
T647PVAIKtLKAGYHPRD; SysPTM
Y930FMAAGyTAIEKHPRD; phosphoELM
Y575SPEDVyFSKSEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S775ATYTTsGGKIPPkinase_TyrPhosphoSitePlus
S570QRARQsPEDVYPhosphoSitePlus; phosphoELM; SysPTM
S790APEAIsYRKFTPkinase_TyrPhosphoSitePlus
S373QCWPEsGECGPfn3PhosphoSitePlus
Y594VDPHTyEDPNQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T898IRLPStSGSEGPhosphoSitePlus; phosphoELM; SysPTM
T774EATYTtSGGKIPkinase_TyrPhosphoSitePlus; SysPTM
T922KMQQYtEHFMASAM_1PhosphoSitePlus
S910PFRTVsEWLESSAM_1PhosphoSitePlus
T647PVAIKtLKAGYPkinase_TyrPhosphoSitePlus; SysPTM
T774EATYTtSGGKIHPRD; SysPTM
S761SDFGLsRVLEDPkinase_TyrPhosphoSitePlus
S899RLPSTsGSEGVPhosphoSitePlus; phosphoELM; SysPTM
S153DEITVsSDFEAEphrin_lbdPhosphoSitePlus
S570QRARQsPEDVYEPHA2HPRD; SysPTM
S790APEAIsYRKFTHPRD
S869FADIVsILDKLPkinase_TyrPhosphoSitePlus

Dephosphorylation site
EPHA2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351209E825*BIOMARTBreast Cancer21930507, 21930502
ENSP00000351209P817LBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000351209G777SGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000351209E663*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351209Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueUp219329653
ENSP00000351209Breast CancerNormal vs. Cancercell lineDown0.2520198662
ENSP00000351209Breast CancerMetastasiscell lineDown0.3320198662

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S897RVSIRLPsTSGSEGVglioblastoma multiforme19573808PhosphoSitePlus
Y594TYVDPHTyEDPNQAVcholangiocellular carcinoma21253578PhosphoSitePlus
Y772Pkinase_TyrEDDPEATyTTSGGKIcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA3_HUMANEPHA2_HUMANligand -> receptorHPMR
EFNA5_HUMANEPHA2_HUMANligand -> receptorHPMR
EFNA4_HUMANEPHA2_HUMANligand -> receptorHPMR
EFNA1_HUMANEPHA2_HUMANligand -> receptorHPMR
EPHA2_HUMANEPHA2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060444branching involved in mammary gland duct morphogenISSbiological_process
GO:0001649osteoblast differentiationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045765regulation of angiogenesisISSbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0031256leading edge membraneIDAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0001570vasculogenesisIEAbiological_process
GO:0010591regulation of lamellipodium assemblyIMPbiological_process
GO:0048013ephrin receptor signaling pathwayIEAbiological_process
GO:0036342post-anal tail morphogenesisIEAbiological_process
GO:0048320axial mesoderm formationIEAbiological_process
GO:0070848response to growth factor stimulusIMPbiological_process
GO:0070309lens fiber cell morphogenesisISSbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0031258lamellipodium membraneIEAcellular_component
GO:0043535regulation of blood vessel endothelial cell migratISSbiological_process
GO:0051898negative regulation of protein kinase B signaling IDAbiological_process
GO:0048570notochord morphogenesisIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0033628regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0043491protein kinase B signaling cascadeIDAbiological_process
GO:0070309lens fiber cell morphogenesisIEAbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0006915apoptotic processIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0070372regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0033598mammary gland epithelial cell proliferationISSbiological_process
GO:0090004positive regulation of establishment of protein loIMPbiological_process
GO:0046849bone remodelingISSbiological_process
GO:0030316osteoclast differentiationIEAbiological_process
GO:0032863activation of Rac GTPase activityIMPbiological_process
GO:0014028notochord formationIEAbiological_process
GO:0060035notochord cell developmentIEAbiological_process
GO:0021915neural tube developmentIEAbiological_process
GO:0046849bone remodelingIEAbiological_process
GO:0043535regulation of blood vessel endothelial cell migratIEAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0030316osteoclast differentiationISSbiological_process
GO:0045765regulation of angiogenesisIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0060326cell chemotaxisIMPbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0033598mammary gland epithelial cell proliferationIEAbiological_process
GO:0030216keratinocyte differentiationIMPbiological_process