Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EFNB1_HUMAN
Description:ephrin-B1 [Source:HGNC Symbol;Acc:3226]
Location:chrX q13.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S338EMPPQsPANIYPhosphoSitePlus; phosphoELM
Y343SPANIyYHPRD; phosphoELM
Y79EYYKLyLVRPEEphrinPhosphoSitePlus
S287LSTLAsPKGGSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y324KVSGDyGHPVYPhosphoSitePlus; HPRD; phosphoELM
T284ALSLStLASPKHPRD
S226GASGGsSGDPDPhosphoSitePlus
Y344PANIYyKV___PhosphoSitePlus
Y313TTENNyCPHYEPhosphoSitePlus; HPRD
Y343SPANIyYKV__PhosphoSitePlus
Y317NYCPHyEKVSGPhosphoSitePlus; HPRD; SysPTM
S321HYEKVsGDYGHPhosphoSitePlus
S218NQEEKsGPGASPhosphoSitePlus
S223SGPGAsGGSSGPhosphoSitePlus
Y329YGHPVyIVQEMPhosphoSitePlus; HPRD; phosphoELM
S227ASGGSsGDPDGPhosphoSitePlus

Dephosphorylation site
EFNB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000204961*347CCOSMICOvarian Cancer21720365
ENSP00000204961R266CCOSMICOvarian Cancer21720365
ENSP00000204961*347SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000204961Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
EFNB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNB1_HUMANEPHB2_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB1_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB3_HUMANligand -> receptorHPMR
EFNB1_HUMANEPHB4_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0001755neural crest cell migrationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0045202synapseISScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0005515protein bindingIEAmolecular_function


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