| UniProt/SwissProt ID: | EFNB1_HUMAN |
| Description: | ephrin-B1 [Source:HGNC Symbol;Acc:3226] |
| Location: | chrX q13.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S338 | EMPPQsPANIY | PhosphoSitePlus; phosphoELM | |
| Y343 | SPANIyY | HPRD; phosphoELM | |
| Y79 | EYYKLyLVRPE | Ephrin | PhosphoSitePlus |
| S287 | LSTLAsPKGGS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y324 | KVSGDyGHPVY | PhosphoSitePlus; HPRD; phosphoELM | |
| T284 | ALSLStLASPK | HPRD | |
| S226 | GASGGsSGDPD | PhosphoSitePlus | |
| Y344 | PANIYyKV___ | PhosphoSitePlus | |
| Y313 | TTENNyCPHYE | PhosphoSitePlus; HPRD | |
| Y343 | SPANIyYKV__ | PhosphoSitePlus | |
| Y317 | NYCPHyEKVSG | PhosphoSitePlus; HPRD; SysPTM | |
| S321 | HYEKVsGDYGH | PhosphoSitePlus | |
| S218 | NQEEKsGPGAS | PhosphoSitePlus | |
| S223 | SGPGAsGGSSG | PhosphoSitePlus | |
| Y329 | YGHPVyIVQEM | PhosphoSitePlus; HPRD; phosphoELM | |
| S227 | ASGGSsGDPDG | PhosphoSitePlus | |
| Dephosphorylation site |
| EFNB1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000204961 | *347C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000204961 | R266C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000204961 | *347S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000204961 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| EFNB1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EFNB1_HUMAN | EPHB2_HUMAN | ligand -> receptor | HPMR |
| EFNB1_HUMAN | EPHB1_HUMAN | ligand -> receptor | HPMR |
| EFNB1_HUMAN | EPHB3_HUMAN | ligand -> receptor | HPMR |
| EFNB1_HUMAN | EPHB4_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009880 | embryonic pattern specification | IEA | biological_process |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0001755 | neural crest cell migration | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0045202 | synapse | ISS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0042102 | positive regulation of T cell proliferation | IEA | biological_process |
| GO:0046875 | ephrin receptor binding | IEA | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |