Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EF1A1_HUMAN
Description:eukaryotic translation elongation factor 1 alpha 1 [Source:HGNC Symbol;Acc:3189]
Location:chr6 q13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T82LWKFEtSKYYVGTP_EFTUPhosphoSitePlus
Y29TGHLIyKCGGIHPRD; phosphoELM; RegPhos
Y167YSQKRyEEIVKGTP_EFTUPhosphoSitePlus
Y85FETSKyYVTIIGTP_EFTUPhosphoSitePlus
Y141HALLAyTLGVKHPRD; phosphoELM; RegPhos
T88SKYYVtIIDAPGTP_EFTUPhosphoSitePlus
S157VNKMDsTEPPYGTP_EFTUPhosphoSitePlus
S383KIDRRsGKKLEGTP_EFTU_D3PhosphoSitePlus
T176VKEVStYIKKIGTP_EFTUPhosphoSitePlus
T432RDMRQtVAVGVPRKCDHPRD
Y177KEVSTyIKKIGGTP_EFTUPhosphoSitePlus
Y254PLQDVyKIGGIPhosphoSitePlus; HPRD
S300HHEALsEALPGGTP_EFTU_D2PhosphoSitePlus
T24GKSTTtGHLIYGTP_EFTUPhosphoSitePlus
T22DSGKStTTGHLGTP_EFTUPhosphoSitePlus
T142ALLAYtLGVKQGTP_EFTUPhosphoSitePlus
T269VGRVEtGVLKPGTP_EFTU_D2PhosphoSitePlus
Y86ETSKYyVTIIDGTP_EFTUPhosphoSitePlus
T242PPTRPtDKPLRHPRD
T23SGKSTtTGHLIGTP_EFTUPhosphoSitePlus
T432RDMRQtVAVGVPKC_groupphosphoELM; RegPhos
T432RDMRQtVAVGVGTP_EFTU_D3PhosphoSitePlus
T133SKNGQtREHALGTP_EFTUPhosphoSitePlus
Y162STEPPySQKRYGTP_EFTUPhosphoSitePlus; SysPTM
Y357QISAGyAPVLDGTP_EFTU_D3PhosphoSitePlus
T158NKMDStEPPYSGTP_EFTUPhosphoSitePlus
Y141HALLAyTLGVKGTP_EFTUPhosphoSitePlus
T6INIVHPRD
Y29TGHLIyKCGGIGTP_EFTUPhosphoSitePlus
S163TEPPYsQKRYEGTP_EFTUPhosphoSitePlus
S76ITIDIsLWKFEGTP_EFTUPhosphoSitePlus
S128FEAGIsKNGQTGTP_EFTUPhosphoSitePlus
T261IGGIGtVPVGRGTP_EFTU_D2PhosphoSitePlus
T432RDMRQtVAVGVPKCdRegPhos
T24GKSTTtGHLIYHPRD
S21VDSGKsTTTGHHPRD
Y86ETSKYyVTIIDHPRD; phosphoELM
Y162STEPPySQKRYHPRD; phosphoELM; RegPhos; SysPTM
S414PMCVEsFSDYPGTP_EFTU_D3PhosphoSitePlus
T106NMITGtSQADCGTP_EFTUPhosphoSitePlus
Y418ESFSDyPPLGRGTP_EFTU_D3PhosphoSitePlus
S21VDSGKsTTTGHGTP_EFTUPhosphoSitePlus

Dephosphorylation site
EF1A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000330054G265DCOSMICSkin Cancer21984974
ENSP00000339063G265DCOSMICSkin Cancer21984974
ENSP00000339053G265DCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000330054Hepatocellular CarcinomaNormal vs. CancertissueUp3.417627933
ENSP00000330054Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp3.218491314
ENSP00000330054Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000330054Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000330054Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000330054Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000330054Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000330054Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S300GTP_EFTU_D2EMHHEALsEALPGDNbreast ductal carcinoma20832312PhosphoSitePlus
Y29GTP_EFTUTTTGHLIyKCGGIDKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCD_HUMANEF1A1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANEF1A1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05134Legionellosis
hsa03013RNA transport

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006412translationTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0006414translational elongationTASbiological_process
GO:0003746translation elongation factor activityIEAmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005853eukaryotic translation elongation factor 1 complexTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component


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