Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DUS6_HUMAN
Description:dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:3072]
Location:chr12 q21.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y255AGEFKyKQIPIDSPcPhosphoSitePlus
S205TLGLSsPCDNRHPRD
S159SCSSSsPPLPVPhosphoSitePlus
S328VKMKKsNISPNDSPcPhosphoSitePlus
S159SCSSSsPPLPVErk2(MAPK1RegPhos
S197TDSDGsPLSNSErk2RegPhos
S351TLGLSsPCDNRPhosphoSitePlus; HPRD
S331KKSNIsPNFNFDSPcPhosphoSitePlus; SysPTM
S159SCSSSsPPLPVErk2RegPhos
S197TDSDGsPLSNSPhosphoSitePlus
S331KKSNIsPNFNFHPRD; phosphoELM; RegPhos; SysPTM
S159SCSSSsPPLPVMAPK3phosphoELM
S159SCSSSsPPLPVErk1(MAPK3RegPhos
S182VKMKKsNISPNHPRD
S300AGISRsVTVTVDSPcPhosphoSitePlus
S159SCSSSsPPLPVMAPK1HPRD; phosphoELM
S174GLRISsDSSSDPhosphoSitePlus
S328VKMKKsNISPNHPRD; phosphoELM
S197TDSDGsPLSNSMAPK1HPRD
S185KKSNIsPNFNFHPRD

Dephosphorylation site
DUS6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000279488A219DCOSMICSkin Cancer21984974

Differential expressed protein
DUS6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DUS6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANDUS6_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANDUS6_HUMANkinase -> substrateRegPhos
MK01_HUMANDUS6_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0051409response to nitrosative stressIEPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0000188inactivation of MAPK activityIDAbiological_process
GO:0070848response to growth factor stimulusIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0005829cytosolIBAcellular_component
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0040036regulation of fibroblast growth factor receptor siIBAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0009953dorsal/ventral pattern formationIBAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0008138protein tyrosine/serine/threonine phosphatase actiIEAmolecular_function
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase aIDAmolecular_function
GO:0060420regulation of heart growthIEAbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0004721phosphoprotein phosphatase activityIEAmolecular_function
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0043065positive regulation of apoptotic processIDAbiological_process
GO:0042663regulation of endodermal cell fate specificationIBAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function