| UniProt/SwissProt ID: | DUS16_HUMAN |
| Description: | dual specificity phosphatase 16 [Source:HGNC Symbol;Acc:17909] |
| Location: | chr12 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S401 | LKRSFsLDIKS | PhosphoSitePlus | |
| S609 | SDRADsRRSWH | PhosphoSitePlus | |
| S446 | KLCQFsPVQEL | Erk2 | RegPhos |
| S446 | KLCQFsPVQEL | Erk2(MAPK1 | RegPhos |
| S612 | ADSRRsWHEES | PhosphoSitePlus | |
| S604 | RRQKPsDRADS | PhosphoSitePlus | |
| S82 | VDIDCsQKVVV | Rhodanese | PhosphoSitePlus |
| S446 | KLCQFsPVQEL | PhosphoSitePlus | |
| S446 | KLCQFsPVQEL | MAPK1 | HPRD; phosphoELM |
| S501 | QRSLLsPLHRS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| DUS16_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000228862 | Q496X | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| DUS16_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DUS16_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | DUS16_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008138 | protein tyrosine/serine/threonine phosphatase acti | IEA | molecular_function |
| GO:0045204 | MAPK export from nucleus | TAS | biological_process |
| GO:0006470 | protein dephosphorylation | IBA | biological_process |
| GO:0043409 | negative regulation of MAPK cascade | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0045209 | MAPK phosphatase export from nucleus, leptomycin B | TAS | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase a | IBA | molecular_function |
| GO:0016311 | dephosphorylation | TAS | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0004721 | phosphoprotein phosphatase activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000188 | inactivation of MAPK activity | IEA | biological_process |