Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DUS16_HUMAN
Description:dual specificity phosphatase 16 [Source:HGNC Symbol;Acc:17909]
Location:chr12 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S401LKRSFsLDIKSPhosphoSitePlus
S609SDRADsRRSWHPhosphoSitePlus
S446KLCQFsPVQELErk2RegPhos
S446KLCQFsPVQELErk2(MAPK1RegPhos
S612ADSRRsWHEESPhosphoSitePlus
S604RRQKPsDRADSPhosphoSitePlus
S82VDIDCsQKVVVRhodanesePhosphoSitePlus
S446KLCQFsPVQELPhosphoSitePlus
S446KLCQFsPVQELMAPK1HPRD; phosphoELM
S501QRSLLsPLHRSPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
DUS16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000228862Q496XBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
DUS16_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DUS16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANDUS16_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008138protein tyrosine/serine/threonine phosphatase actiIEAmolecular_function
GO:0045204MAPK export from nucleusTASbiological_process
GO:0006470protein dephosphorylationIBAbiological_process
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0045209MAPK phosphatase export from nucleus, leptomycin BTASbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase aIBAmolecular_function
GO:0016311dephosphorylationTASbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0004721phosphoprotein phosphatase activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000188inactivation of MAPK activityIEAbiological_process


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