| UniProt/SwissProt ID: | DPYL3_HUMAN |
| Description: | dihydropyrimidinase-like 3 [Source:HGNC Symbol;Acc:3015] |
| Location: | chr5 q32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y477 | SPFSDyVYKRI | PhosphoSitePlus | |
| S518 | GTPAGsARGSP | PhosphoSitePlus; HPRD | |
| S259 | KVMSKsAADLI | Amidohydro_1 | PhosphoSitePlus |
| Y499 | VPRGMyDGPVF | PhosphoSitePlus | |
| T507 | PVFDLtTTPKG | PhosphoSitePlus | |
| S2 | ____MsYQGKK | PhosphoSitePlus | |
| S522 | GSARGsPTRPN | PhosphoSitePlus; HPRD | |
| S539 | HQSGFsLSGTQ | PhosphoSitePlus | |
| T514 | TPKGGtPAGSA | PhosphoSitePlus; HPRD | |
| S551 | DEGVRsASKRI | HPRD | |
| S257 | VTKVMsKSAAD | Amidohydro_1 | PhosphoSitePlus |
| T509 | FDLTTtPKGGT | PhosphoSitePlus; HPRD; SysPTM | |
| Y431 | QSAAEyNIFEG | PhosphoSitePlus | |
| T524 | ARGSPtRPNPP | PhosphoSitePlus; HPRD | |
| S30 | VNDDQsFYADI | PhosphoSitePlus | |
| Y32 | DDQSFyADIYM | PhosphoSitePlus | |
| Y251 | TNCPLyVTKVM | Amidohydro_1 | PhosphoSitePlus |
| S472 | RFIPCsPFSDY | PhosphoSitePlus | |
| T508 | VFDLTtTPKGG | PhosphoSitePlus; HPRD | |
| S308 | TSPPLsPDPTT | Amidohydro_1 | PhosphoSitePlus |
| T253 | CPLYVtKVMSK | Amidohydro_1 | PhosphoSitePlus |
| S304 | AAFVTsPPLSP | Amidohydro_1 | PhosphoSitePlus |
| Dephosphorylation site |
| DPYL3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000381526 | A119T | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000381526 | Q340E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000343690 | *685S | COSMIC | Breast Cancer | 16959974 | ENSP00000381526 | A243S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000343690 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.38 | 19142970 | ENSP00000343690 | Breast Cancer | Normal vs. Cancer | tissue | Down | 20560667 |
| Hyperphosphorylation site |
| DPYL3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK2_HUMAN | DPYL3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | DPYL3_HUMAN | kinase -> substrate | RegPhos |
| GSK3B_HUMAN | DPYL3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DPYL3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007399 | nervous system development | IEA | biological_process |
| GO:0031941 | filamentous actin | IEA | cellular_component |
| GO:0010976 | positive regulation of neuron projection developme | IEA | biological_process |
| GO:0051017 | actin filament bundle assembly | IEA | biological_process |
| GO:0006208 | pyrimidine nucleobase catabolic process | IEA | biological_process |
| GO:0030336 | negative regulation of cell migration | IEA | biological_process |
| GO:0035374 | chondroitin sulfate binding | IEA | molecular_function |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030426 | growth cone | IEA | cellular_component |
| GO:0010977 | negative regulation of neuron projection developme | IEA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0044297 | cell body | IEA | cellular_component |
| GO:0071345 | cellular response to cytokine stimulus | IEA | biological_process |
| GO:0051491 | positive regulation of filopodium assembly | IEA | biological_process |
| GO:0051764 | actin crosslink formation | IEA | biological_process |
| GO:0048678 | response to axon injury | IEA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0051219 | phosphoprotein binding | IEA | molecular_function |
| GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but | IEA | molecular_function |
| GO:0070382 | exocytic vesicle | ISS | cellular_component |
| GO:0048666 | neuron development | IEA | biological_process |
| GO:0051260 | protein homooligomerization | IEA | biological_process |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but | IEA | molecular_function |