Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DLL1_HUMAN
Description:delta-like 1 (Drosophila) [Source:HGNC Symbol;Acc:2908]
Location:chr6 q27
Node attribute:glycosylation(target); ligand; cleavage(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S603REKDIsVSIIGPhosphoSitePlus
Y641YPAVDyNLVQDPhosphoSitePlus
T702STSKDtKYQSVPhosphoSitePlus

Dephosphorylation site
DLL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355718A528VCOSMICLung Cancer20668451
ENSP00000355718G456VCOSMICLung Cancer20668451
ENSP00000355718Q705HBIOMARTBreast Cancer21930507, 21930502
ENSP00000355718T321KCOSMICLung Cancer20668451

Differential expressed protein
DLL1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DLL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DLL1_HUMANNOTC1_HUMANligand -> receptorHPMR
OFUT1_HUMANDLL1_HUMANglycosylationNetPath
MFNG_HUMANDLL1_HUMANglycosylationNetPath
ADA10_HUMANDLL1_HUMANcleavageNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0007219Notch signaling pathwayNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001757somite specificationIEAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0070986left/right axis specificationIEAbiological_process
GO:0030097hemopoiesisNASbiological_process
GO:0030154cell differentiationTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007220Notch receptor processingTASbiological_process
GO:0072014proximal tubule developmentIEAbiological_process
GO:0005112Notch bindingIEAmolecular_function
GO:0045608negative regulation of auditory receptor cell diffIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0072070loop of Henle developmentIEAbiological_process
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0001947heart loopingIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0007368determination of left/right symmetryISSbiological_process
GO:0005112Notch bindingIPImolecular_function
GO:0045638negative regulation of myeloid cell differentiatioIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005887integral to plasma membraneNAScellular_component
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0007386compartment pattern specificationIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0001947heart loopingISSbiological_process
GO:0030155regulation of cell adhesionTASbiological_process
GO:0097150neuronal stem cell maintenanceIEPbiological_process
GO:0016020membraneIEAcellular_component
GO:0001756somitogenesisIEAbiological_process
GO:0001709cell fate determinationNASbiological_process
GO:0005515protein bindingIEAmolecular_function


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