Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DLG1_HUMAN
Description:discs, large homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:2900]
Location:chr3 q29
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y409KPTSMyMNDGYPDZ_assocPhosphoSitePlus
S301LKEAGsIVRLYRegPhos
S158SHSHIsPIKPTMAGUK_N_PESTPhosphoSitePlus; SysPTM
Y110VEKYRyQDEDTHPRD; phosphoELM
S158SHSHIsPIKPTHPRD; SysPTM
S102LPSSLsPSVEKPhosphoSitePlus; HPRD
S443GQTPAsPARYSPDZ_assocPhosphoSitePlus
S23YRSKLsQTEDRHPRD
Y447ASPARySPVSKPDZ_assocPhosphoSitePlus
S232LERGNsGLGFSRegPhos
S619HVINAsDDEWWSH3_2PhosphoSitePlus
S567EQMMNsSISSGHPRD; phosphoELM
Y399TSDFVyLKVAKPDZPhosphoSitePlus
S232LERGNsGLGFSCaMK2_groupRegPhos
T115YQDEDtPPQEHHPRD; phosphoELM
S619HVINAsDDEWWphosphoELM
S709VTSNAsDSESSHPRD
Y409KPTSMyMNDGYHPRD
S573SISSGsGSLRTPhosphoSitePlus; HPRD
T115YQDEDtPPQEHMAGUK_N_PESTPhosphoSitePlus
S598DKTKDsGLPSQSH3_2PhosphoSitePlus
T126ISPQItNEVIGMAGUK_N_PESTPhosphoSitePlus
S706DQHVTsNASDSHPRD
T578SGSLRtSQKRSPhosphoSitePlus
S684LKHVTsNASDSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S122PQEHIsPQITNHPRD; phosphoELM
S232LERGNsGLGFSCaMK2aRegPhos
Y399TSDFVyLKVAKRegPhos
T791NHLYGtSVQSVGuanylate_kinPhosphoSitePlus
Y760VDGRDyHFVTSGuanylate_kinPhosphoSitePlus
Y108PSVEKyRYQDEHPRD; SysPTM
T351NSIYVtKIIEGPDZPhosphoSitePlus
S232LERGNsGLGFSCaM-KII_groupphosphoELM
S579GSLRTsQKRSLPhosphoSitePlus
S155GFVSHsHISPIHPRD
S892IIEEQsGSYIWPhosphoSitePlus
S451RYSPVsKAVLGPDZ_assocPhosphoSitePlus
Y824QIAQLyPISIFGuanylate_kinPhosphoSitePlus
Y789YNNHLyGTSVQGuanylate_kinPhosphoSitePlus
S301LKEAGsIVRLYPDZPhosphoSitePlus
S122PQEHIsPQITNMAGUK_N_PESTPhosphoSitePlus
Y784IEAGQyNNHLYGuanylate_kinPhosphoSitePlus
S570MNSSIsSGSGSHPRD
T764DYHFVtSREQMGuanylate_kinPhosphoSitePlus
S138ELVHVsEKNLSMAGUK_N_PESTPhosphoSitePlus
S23YRSKLsQTEDRL27_1PhosphoSitePlus
S448SPARYsPVSKAPDZ_assocPhosphoSitePlus
S143SEKNLsEIENVHPRD; SysPTM
S687VTSNAsDSESSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y895EQSGSyIWVPAPhosphoSitePlus
S765YHFVTsREQMEGuanylate_kinPhosphoSitePlus
S571NSSISsGSGSLPhosphoSitePlus; HPRD; phosphoELM
S232LERGNsGLGFSCAMK2AHPRD
S575SSGSGsLRTSQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T705ADQHVtSNASDHPRD
Y110VEKYRyQDEDTMAGUK_N_PESTPhosphoSitePlus
T657RARLKtVKFNSPhosphoSitePlus
S568QMMNSsISSGSPhosphoSitePlus; HPRD
Y414YMNDGyAPPDIPDZ_assocPhosphoSitePlus
Y753RPKRDyEVDGRGuanylate_kinPhosphoSitePlus
Y782VDGRDyHFVTSHPRD
Y760VDGRDyHFVTSHPRD; phosphoELM
T683GLKHVtSNASDRegPhos

Dephosphorylation site
DLG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000345731P464RCOSMICOvarian Cancer21720365
ENSP00000345731P921SCOSMICSkin Cancer21984974
ENSP00000345731S347NCOSMICOvarian Cancer21720365
ENSP00000345731K760ECOSMICOvarian Cancer21720365

Differential expressed protein
DLG1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DLG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC2A_HUMANDLG1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANDLG1_HUMANkinase -> substrateRegPhos
KCC4_HUMANDLG1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031579membrane raft organizationIEAbiological_process
GO:0007015actin filament organizationIDAbiological_process
GO:0072659protein localization to plasma membraneIMPbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0002369T cell cytokine productionIEAbiological_process
GO:0030866cortical actin cytoskeleton organizationIDAbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0005874microtubuleIDAcellular_component
GO:0030054cell junctionIEAcellular_component
GO:0033268node of RanvierIEAcellular_component
GO:0016328lateral plasma membraneIEAcellular_component
GO:0031594neuromuscular junctionIEAcellular_component
GO:0030838positive regulation of actin filament polymerizatiIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0097025MPP7-DLG1-LIN7 complexIDAcellular_component
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0032147activation of protein kinase activityIEAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0001657ureteric bud developmentIEAbiological_process
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0001771immunological synapse formationIEAbiological_process
GO:0043219lateral loopIEAcellular_component
GO:0015459potassium channel regulator activityNASmolecular_function
GO:0001772immunological synapseIEAcellular_component
GO:0031434mitogen-activated protein kinase kinase bindingIPImolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0042982amyloid precursor protein metabolic processIEAbiological_process
GO:0001935endothelial cell proliferationIDAbiological_process
GO:0030432peristalsisIEAbiological_process
GO:0008104protein localizationIEAbiological_process
GO:0031575mitotic cell cycle G1/S transition checkpointNASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0097016L27 domain bindingIPImolecular_function
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0004385guanylate kinase activityTASmolecular_function
GO:0016337cell-cell adhesionIDAbiological_process
GO:0031253cell projection membraneIEAcellular_component
GO:0090004positive regulation of establishment of protein loIDAbiological_process
GO:0005923tight junctionIDAcellular_component
GO:0060022hard palate developmentIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0042110T cell activationIEAbiological_process
GO:0043268positive regulation of potassium ion transportIDAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0007163establishment or maintenance of cell polarityTASbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0048729tissue morphogenesisIEAbiological_process
GO:0032947protein complex scaffoldIEAmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0019902phosphatase bindingIPImolecular_function
GO:0009898internal side of plasma membraneIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0070830tight junction assemblyIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0048608reproductive structure developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042391regulation of membrane potentialIEAbiological_process
GO:0045930negative regulation of mitotic cell cycleIMPbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0004721phosphoprotein phosphatase activityTASmolecular_function
GO:0045121membrane raftIEAcellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0035748myelin sheath abaxonal regionIEAcellular_component
GO:0042383sarcolemmaIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005911cell-cell junctionIDAcellular_component
GO:0008092cytoskeletal protein bindingTASmolecular_function
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0045202synapseIEAcellular_component