Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DKK2_HUMAN
Description:dickkopf 2 homolog (Xenopus laevis) [Source:HGNC Symbol;Acc:2892]
Location:chr4 q25
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y155RNHGHySNHDLPhosphoSitePlus
S97SPHQGsSACMVDickkopf_NPhosphoSitePlus
S156NHGHYsNHDLGPhosphoSitePlus
S92GRYCHsPHQGSDickkopf_NPhosphoSitePlus
Y89CEVGRyCHSPHDickkopf_NPhosphoSitePlus
S98PHQGSsACMVCDickkopf_NPhosphoSitePlus

Dephosphorylation site
DKK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000285311G221DCOSMICLung Cancer
ENSP00000285311R112GCOSMICOvarian Cancer21720365
ENSP00000285311C127SCOSMICOvarian Cancer21720365
ENSP00000285311L253FCOSMICHead and Neck Cancer21798893
ENSP00000285311S222FCOSMICMelanoma
ENSP00000285311V241IBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
DKK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DKK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DKK2_HUMANLRP6_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIDAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007275multicellular organismal developmentIEAbiological_process


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