Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DKK1_HUMAN
Description:dickkopf 1 homolog (Xenopus laevis) [Source:HGNC Symbol;Acc:2891]
Location:chr10 q21.1
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T221EGQVCtKHRRKPhosphoSitePlus
Y132CCPGNyCKNGIDickkopf_NPhosphoSitePlus
S258QASNSsRLHTCPhosphoSitePlus
S255DHHQAsNSSRLPhosphoSitePlus
T262SSRLHtCQRH_PhosphoSitePlus
S257HQASNsSRLHTPhosphoSitePlus

Dephosphorylation site
DKK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363081T10NTCGAOvarian Cancer21720365, 18772890
ENSP00000363081C237*COSMICHead and Neck Cancer21798893
ENSP00000363081R225KCOSMICLung Cancer
ENSP00000363081R224SCOSMICHead and Neck Cancer21798893
ENSP00000363081T10NCOSMICOvarian Cancer21720365
ENSP00000363081S207YCOSMICRenal Cancer20054297

Differential expressed protein
DKK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DKK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DKK1_HUMANKREM1_HUMANligand -> receptorHPMR
DKK1_HUMANKREM2_HUMANligand -> receptorHPMR
DKK1_HUMANLRP6_HUMANligand -> receptorHPMR
DKK1_HUMANLRP6_HUMANotherKEGG
P53_HUMANDKK1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048642negative regulation of skeletal muscle tissue deveIEAbiological_process
GO:0031333negative regulation of protein complex assemblyIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0090244Wnt receptor signaling pathway involved in somitogIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0060323head morphogenesisIEAbiological_process
GO:0060394negative regulation of pathway-restricted SMAD proIDAbiological_process
GO:0090082positive regulation of heart induction by negativeISSbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0060325face morphogenesisIEAbiological_process
GO:0090082positive regulation of heart induction by negativeIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0008083growth factor activityTASmolecular_function
GO:0002090regulation of receptor internalizationIDAbiological_process
GO:0050750low-density lipoprotein particle receptor bindingIDAmolecular_function
GO:0042662negative regulation of mesodermal cell fate specifIDAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0042663regulation of endodermal cell fate specificationIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:1901296negative regulation of canonical Wnt receptor signIDAbiological_process
GO:2000726negative regulation of cardiac muscle cell differeIDAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIDAbiological_process
GO:0000904cell morphogenesis involved in differentiationIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0033137negative regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0030111regulation of Wnt receptor signaling pathwayIEAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0032526response to retinoic acidIEAbiological_process
GO:1900116extracellular negative regulation of signal transdIDAbiological_process
GO:0001706endoderm formationIEAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0048019receptor antagonist activityIDAmolecular_function
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process