| UniProt/SwissProt ID: | DHH_HUMAN |
| Description: | desert hedgehog [Source:HGNC Symbol;Acc:2865] |
| Location: | chr12 q13.12 |
| Node attribute: | ligand |
| Phosphorylation site |
| DHH_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| DHH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000266991 | V41L | COSMIC | Lung Cancer | 20668451 |
| ENSP00000266991 | F87L | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| DHH_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DHH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DHH_HUMAN | HHIP_HUMAN | ligand -> receptor | HPMR |
| DHH_HUMAN | PTC2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04340 | Hedgehog signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008270 | zinc ion binding | IDA | molecular_function |
| GO:0030238 | male sex determination | IEA | biological_process |
| GO:0005113 | patched binding | IEA | molecular_function |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0050810 | regulation of steroid biosynthetic process | IEA | biological_process |
| GO:0007267 | cell-cell signaling | IEA | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0033327 | Leydig cell differentiation | IEA | biological_process |
| GO:0005509 | calcium ion binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007286 | spermatid development | IEA | biological_process |
| GO:0022402 | cell cycle process | IEA | biological_process |