Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTC2_HUMAN
Description:patched 2 [Source:HGNC Symbol;Acc:9586]
Location:chr1 p34.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T15LPPSYtPPARTPhosphoSitePlus
T2____MtRSPPLPhosphoSitePlus
T775LPPPAtQAPRTPatchedPhosphoSitePlus
S1152SSLPQsFARVTHPRD
S1194SSGNLsSRGPGPhosphoSitePlus
T1157SFARVtTSMTVHPRD
S4__MTRsPPLREPhosphoSitePlus

Dephosphorylation site
PTC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361266Q24HDing2008, COSMICLung Cancer18948947
ENSP00000361266P853LCOSMICMelanoma21499247
ENSP00000361266A677VCOSMICCentral Nervous System Neoplasms18772396
ENSP00000361266W293SCOSMICBreast Cancer20393555
ENSP00000361266W193LCOSMICLung Cancer20668451
ENSP00000361266K158*COSMICOvarian Cancer21720365
ENSP00000361266R92PCOSMICBreast Cancer20668451
ENSP00000361266D1082YDing2008, COSMICLung Cancer18948947
ENSP00000361266A68fs*4COSMICLung Cancer
ENSP00000361266E738KCOSMICBreast Cancer20668451
ENSP00000361266P1117LCOSMICBreast Cancer20668451
ENSP00000361266G171ABIOMARTPancreatic Cancer21930507, 21930502
ENSP00000361266L403MCOSMICLung Cancer20668451

Differential expressed protein
PTC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DHH_HUMANPTC2_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
hsa04340Hedgehog signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045879negative regulation of smoothened signaling pathwaTASbiological_process
GO:0008158hedgehog receptor activityTASmolecular_function
GO:0043588skin developmentIEAbiological_process
GO:0005119smoothened bindingIPImolecular_function
GO:0097108hedgehog family protein bindingTASmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0042633hair cycleIEAbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0016020membraneIEAcellular_component


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