| UniProt/SwissProt ID: | DEST_HUMAN |
| Description: | destrin (actin depolymerizing factor) [Source:HGNC Symbol;Acc:15750] |
| Location: | chr20 p12.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S7 | PEEI | HPRD | |
| S24 | KVRKCsTPEEI | HPRD | |
| S3 | VQVA | HPRD | |
| Y16 | VCRIFyDMKVR | PhosphoSitePlus | |
| Y117 | KSKMIyASSKD | Cofilin_ADF | PhosphoSitePlus |
| S3 | MASGVqVA | TESK2 | RegPhos |
| T25 | VRKCStPEEIK | Cofilin_ADF | PhosphoSitePlus |
| Y85 | CRYALyDASFE | Cofilin_ADF | PhosphoSitePlus |
| S3 | MASGVqVA | RegPhos | |
| S3 | VQVA | TESK2 | HPRD |
| S3 | ___MAsGVQVA | PhosphoSitePlus | |
| S24 | KVRKCsTPEEI | Cofilin_ADF | PhosphoSitePlus |
| Dephosphorylation site |
| DEST_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000246069 | R21C | COSMIC | Melanoma | 21499247 | ENSP00000246069 | G139E | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000246069 | G139E | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000246069 | Gastric Cancer | Metastasis | cell line | Down | 0.5 | 17022644 | ENSP00000246069 | Ovarian Cancer | Treatment (platinum-sensitive vs. platinum-resistant) | cell line | Up | 2 | 17269733 | ENSP00000246069 | Ovarian Cancer | Treatment (platinum-sensitive vs. platinum-resistant) | cell line | Up | 2.6 | 17269733 | ENSP00000246069 | Ovarian Cancer | Treatment (platinum-sensitive vs. platinum-resistant) | cell line | Up | 2.1 | 17269733 | ENSP00000246069 | Ovarian Cancer | Treatment (platinum-sensitive vs. platinum-resistant) | cell line | Up | 2.1 | 17269733 | ENSP00000246069 | Breast Cancer | Normal vs. Cancer | tissue | Up | 15767701 | ENSP00000246069 | Gastric Cancer | Metastasis | cell line | Down | 0.5 | 17022644 | ENSP00000246069 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2 | 15526344 |
| Hyperphosphorylation site |
| DEST_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TESK2_HUMAN | DEST_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | DEST_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| DEST_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000910 | cytokinesis | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0030864 | cortical actin cytoskeleton | IEA | cellular_component |
| GO:0006928 | cellular component movement | IEA | biological_process |
| GO:0030836 | positive regulation of actin filament depolymeriza | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0008154 | actin polymerization or depolymerization | TAS | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0051014 | actin filament severing | TAS | biological_process |