Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDIT3_HUMAN
Description:DNA-damage-inducible transcript 3 [Source:HGNC Symbol;Acc:2726]
Location:chr12 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S30LQEVLsSDENGCSNK2A1HPRD
S79TSTSQsPHSPDp38_groupphosphoELM; RegPhos
S82SQSPHsPDSSQPeptidase_S64; CDC45; MacPhosphoSitePlus
S31QEVLSsDENGGCK2a1RegPhos
S31QEVLSsDENGGCK2_alphaphosphoELM
S30LQEVLsSDENGPeptidase_S64; CDC45; MacPhosphoSitePlus
S14SFGTLsSWELECK2a1-rsRegPhos
S82SQSPHsPDSSQp38aRegPhos
S31QEVLSsDENGGCK2a1(CK2 alphaRegPhos
S79TSTSQsPHSPDPeptidase_S64; CDC45; MacPhosphoSitePlus
S31QEVLSsDENGGCK2a1-rsRegPhos
S31QEVLSsDENGGCSNK2A1HPRD
S14SFGTLsSWELECK2a1RegPhos
S15FGTLSsWELEACK2a1-rsRegPhos
S82SQSPHsPDSSQMAPK14HPRD
S79TSTSQsPHSPDMAPK14HPRD
S31QEVLSsDENGGCK2_groupphosphoELM; RegPhos
S15FGTLSsWELEACSNK2A1HPRD
S15FGTLSsWELEACK2_groupphosphoELM; RegPhos
T64SLAWLtEEEPEPeptidase_S64; CDC45; MacPhosphoSitePlus
S14SFGTLsSWELECSNK2A1HPRD
S31QEVLSsDENGGPeptidase_S64; CDC45; MacPhosphoSitePlus
S15FGTLSsWELEACK2_alphaphosphoELM
S82SQSPHsPDSSQp38_groupphosphoELM; RegPhos
S30LQEVLsSDENGCK2a1-rsRegPhos
S30LQEVLsSDENGCK2_groupphosphoELM; RegPhos
S15FGTLSsWELEAPhosphoSitePlus
S14SFGTLsSWELECK2_groupphosphoELM; RegPhos
S14SFGTLsSWELECK2_alphaphosphoELM
S14SFGTLsSWELECK2a1(CK2 alphaRegPhos
T54SKIFTtLDPASPeptidase_S64; CDC45; MacPhosphoSitePlus
S79TSTSQsPHSPDp38aRegPhos
S14SFGTLsSWELEPhosphoSitePlus
S30LQEVLsSDENGCK2a1RegPhos
S49NEEEEsKIFTTPeptidase_S64; CDC45; MacPhosphoSitePlus
S15FGTLSsWELEACK2a1(CK2 alphaRegPhos
S15FGTLSsWELEACK2a1RegPhos

Dephosphorylation site
DDIT3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000340671A115TCOSMICOvarian Cancer21720365
ENSP00000340671G35ECOSMICMelanoma
ENSP00000340671E4KCOSMICLung Cancer20668451
ENSP00000447188D32YCOSMICCentral Nervous System Neoplasms18772890
ENSP00000447188G35ECOSMICMelanoma
ENSP00000447188L25RCOSMICOvarian Cancer21720365
ENSP00000447188A115TCOSMICOvarian Cancer21720365
ENSP00000340671L25RCOSMICOvarian Cancer21720365
ENSP00000340671A115VSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000447188E4KCOSMICLung Cancer20668451
ENSP00000340671A115VBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000340671D32YCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
DDIT3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DDIT3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANDDIT3_HUMANkinase -> substrateKEGG; HPRD
CSK21_HUMANDDIT3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa04010MAPK signaling pathway
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000016negative regulation of determination of dorsal ideIDAbiological_process
GO:0006974response to DNA damage stimulusTASbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043161proteasomal ubiquitin-dependent protein catabolic IDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0090090negative regulation of canonical Wnt receptor signISSbiological_process
GO:0042789mRNA transcription from RNA polymerase II promoterIDAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0070059intrinsic apoptotic signaling pathway in response IMPbiological_process
GO:0006986response to unfolded proteinIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0007050cell cycle arrestIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0045454cell redox homeostasisIDAbiological_process
GO:0034976response to endoplasmic reticulum stressIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032757positive regulation of interleukin-8 productionIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0043620regulation of DNA-dependent transcription in respoTASbiological_process
GO:0044324regulation of transcription involved in anterior/pISSbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process