Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDB2_HUMAN
Description:damage-specific DNA binding protein 2, 48kDa [Source:HGNC Symbol;Acc:2718]
Location:chr11 p11.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S26NKRSRsPLELEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S24PRNKRsRSPLEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S116DRRATsLAWHPWD40PhosphoSitePlus
S131TVAVGsKGGDIWD40PhosphoSitePlus
T122LAWHPtHPSTVWD40PhosphoSitePlus

Dephosphorylation site
DDB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256996T338PTCGAOvarian Cancer21720365, 18772890
ENSP00000256996T338PCOSMICOvarian Cancer21720365

Differential expressed protein
DDB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DDB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P53_HUMANDDB2_HUMANTF -> target geneKEGG
P53_HUMANDDB2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03420Nucleotide excision repair
hsa04115p53 signaling pathway
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043234protein complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0003684damaged DNA bindingTASmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0006290pyrimidine dimer repairIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0000209protein polyubiquitinationIDAbiological_process
GO:0006289nucleotide-excision repairTASbiological_process
GO:0009411response to UVIDAbiological_process
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function


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