| UniProt/SwissProt ID: | DDB2_HUMAN |
| Description: | damage-specific DNA binding protein 2, 48kDa [Source:HGNC Symbol;Acc:2718] |
| Location: | chr11 p11.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S26 | NKRSRsPLELE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S24 | PRNKRsRSPLE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S116 | DRRATsLAWHP | WD40 | PhosphoSitePlus |
| S131 | TVAVGsKGGDI | WD40 | PhosphoSitePlus |
| T122 | LAWHPtHPSTV | WD40 | PhosphoSitePlus |
| Dephosphorylation site |
| DDB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256996 | T338P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000256996 | T338P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| DDB2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DDB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | DDB2_HUMAN | TF -> target gene | KEGG |
| P53_HUMAN | DDB2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03420 | Nucleotide excision repair |
| hsa04115 | p53 signaling pathway |
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043234 | protein complex | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0003684 | damaged DNA binding | TAS | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0006290 | pyrimidine dimer repair | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051865 | protein autoubiquitination | IDA | biological_process |
| GO:0000209 | protein polyubiquitination | IDA | biological_process |
| GO:0006289 | nucleotide-excision repair | TAS | biological_process |
| GO:0009411 | response to UV | IDA | biological_process |
| GO:0000718 | nucleotide-excision repair, DNA damage removal | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0004842 | ubiquitin-protein ligase activity | IDA | molecular_function |