| UniProt/SwissProt ID: | DAF_HUMAN |
| Description: | CD55 molecule, decay accelerating factor for complement (Cromer blood group) [Source:HGNC Symbol;Acc:2665] |
| Location: | chr1 q32.2 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S334 | RSTPVsRTTKH | PhosphoSitePlus | |
| Y245 | RDHYGyRQSVT | Sushi | PhosphoSitePlus |
| S162 | FCKKKsCPNPG | PhosphoSitePlus | |
| Y266 | GEHSIyCTVNN | Sushi | PhosphoSitePlus |
| Y251 | RQSVTyACNKG | Sushi | PhosphoSitePlus |
| S140 | REPSLsPKLTC | HPRD | |
| S140 | REPSLsPKLTC | Sushi | PhosphoSitePlus |
| Dephosphorylation site |
| DAF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356031 | H341Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000316333 | H341Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356031 | L38I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356031 | Breast Cancer | Normal vs. Cancer | tissue | Up | 2.1 | 16470630 | ENSP00000356031 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| DAF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DAF_HUMAN | CD97_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04640 | Hematopoietic cell lineage |
| hsa04610 | Complement and coagulation cascades |
| hsa05416 | Viral myocarditis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043434 | response to peptide hormone stimulus | IEA | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0060137 | maternal process involved in parturition | IEA | biological_process |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0045730 | respiratory burst | NAS | biological_process |
| GO:0004857 | enzyme inhibitor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0045121 | membrane raft | IDA | cellular_component |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0031225 | anchored to membrane | IEA | cellular_component |
| GO:0045916 | negative regulation of complement activation | IEA | biological_process |
| GO:0043086 | negative regulation of catalytic activity | IEA | biological_process |
| GO:0016324 | apical plasma membrane | IEA | cellular_component |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0006958 | complement activation, classical pathway | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |