| UniProt/SwissProt ID: | CD97_HUMAN |
| Description: | CD97 molecule [Source:HGNC Symbol;Acc:1711] |
| Location: | chr19 p13.12 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S725 | FTSTTsGTGHN | HPRD | |
| T820 | STTSGtGHNQT | HPRD | |
| S738 | RALRAsES | HPRD | |
| S722 | YSEFTsTTSGT | HPRD | |
| S766 | YSEFTsTTSGT | HPRD | |
| S811 | GGSKYsEFTST | PhosphoSitePlus | |
| S784 | LRASEs | HPRD | |
| S818 | FTSTTsGTGHN | PhosphoSitePlus; HPRD | |
| T727 | STTSGtGHNQT | HPRD | |
| S782 | RALRAsES | HPRD | |
| Y810 | AGGSKySEFTS | PhosphoSitePlus | |
| S815 | YSEFTsTTSGT | PhosphoSitePlus; HPRD | |
| S740 | LRASEs | HPRD | |
| S831 | RALRAsES | HPRD; phosphoELM | |
| T771 | STTSGtGHNQT | HPRD | |
| S831 | RALRAsESGI_ | PhosphoSitePlus | |
| S833 | LRASEs | HPRD; phosphoELM | |
| T816 | SEFTStTSGTG | PhosphoSitePlus | |
| S769 | FTSTTsGTGHN | HPRD | |
| S833 | LRASEsGI___ | PhosphoSitePlus | |
| Dephosphorylation site |
| CD97_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000242786 | A8P | COSMIC | Breast Cancer | 17932254 | ENSP00000242786 | K281I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000242786 | N406D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000242786 | E431* | COSMIC | Ovarian Cancer | 20826764 | ENSP00000242786 | P199L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000349918 | K232I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000349918 | N357D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000242786 | S35A | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000242786 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Up | 4.3 | 19800108 |
| Hyperphosphorylation site |
| CD97_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DAF_HUMAN | CD97_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| CD97_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007218 | neuropeptide signaling pathway | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0006928 | cellular component movement | TAS | biological_process |