Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSF2_HUMAN
Description:colony stimulating factor 2 (granulocyte-macrophage) [Source:HGNC Symbol;Acc:2434]
Location:chr5 q31.1
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T95LKGPLtMMASHGM_CSFPhosphoSitePlus
T119ATQIItFESFKGM_CSFPhosphoSitePlus
S86QGLRGsLTKLKGM_CSFPhosphoSitePlus

Dephosphorylation site
CSF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296871H100NCOSMICSkin Cancer21984974

Differential expressed protein
CSF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CSF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSF2_HUMANCSF3R_HUMANligand -> receptorHPMR
FOXP3_HUMANCSF2_HUMANTF -> target geneTRANSFAC
PEBB_HUMANCSF2_HUMANTF -> target geneTRANSFAC
TYY1_HUMANCSF2_HUMANTF -> target geneTRANSFAC
NFAC2_HUMANCSF2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05146Amoebiasis
hsa04660T cell receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05323Rheumatoid arthritis
hsa05132Salmonella infection
hsa04650Natural killer cell mediated cytotoxicity
hsa04664Fc epsilon RI signaling pathway
hsa05166HTLV-I infection
hsa04640Hematopoietic cell lineage
hsa05202Transcriptional misregulation in cancer
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceIEAcellular_component
GO:0045918negative regulation of cytolysisIDAbiological_process
GO:0010744positive regulation of macrophage derived foam celIDAbiological_process
GO:0032747positive regulation of interleukin-23 productionIDAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0043011myeloid dendritic cell differentiationIEAbiological_process
GO:0097028dendritic cell differentiationIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0042045epithelial fluid transportIEAbiological_process
GO:0010628positive regulation of gene expressionIDAbiological_process
GO:0042116macrophage activationIEAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0071803positive regulation of podosome assemblyIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0097028dendritic cell differentiationIDAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005129granulocyte macrophage colony-stimulating factor rIEAmolecular_function


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