| UniProt/SwissProt ID: | PEBB_HUMAN |
| Description: | core-binding factor, beta subunit [Source:HGNC Symbol;Acc:1539] |
| Location: | chr16 q22.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y85 | TPSREyVDLER | CBF_beta | PhosphoSitePlus |
| S173 | RQQDPsPGSNL | HPRD | |
| S176 | DPSPGsNLGGG | HPRD | |
| T150 | EARRRtREFED | CBF_beta | PhosphoSitePlus |
| Y96 | EAGKVyLKAPM | CBF_beta | PhosphoSitePlus |
| Dephosphorylation site |
| PEBB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000415151 | R9G | COSMIC | Breast Cancer | 20668451 | ENSP00000415151 | R83* | COSMIC | Breast Cancer | 20668451 | ENSP00000415151 | E152* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000290858 | E152* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000290858 | R83* | COSMIC | Breast Cancer | 20668451 | ENSP00000290858 | P100A | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000290858 | Gastric Cancer | Metastasis | cell line | Down | 0.31 | 17022644 | ENSP00000290858 | Gastric Cancer | Metastasis | cell line | Down | 0.31 | 17022644 |
| Hyperphosphorylation site |
| PEBB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PEBB_HUMAN | CSF2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PEBB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001503 | ossification | IEA | biological_process |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0030098 | lymphocyte differentiation | IEA | biological_process |
| GO:0003713 | transcription coactivator activity | IEA | molecular_function |
| GO:0048469 | cell maturation | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0030099 | myeloid cell differentiation | IEA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0060216 | definitive hemopoiesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001649 | osteoblast differentiation | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |