| UniProt/SwissProt ID: | CRTC1_HUMAN |
| Description: | CREB regulated transcription coactivator 1 [Source:HGNC Symbol;Acc:16062] |
| Location: | chr19 p13.11 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S153 | RTNSDsALHQS | PhosphoSitePlus; HPRD | |
| S48 | LQLQKsQYLQL | PhosphoSitePlus | |
| S277 | LSSSSsTGNLA | RegPhos | |
| T149 | TSWRRtNSDSA | RegPhos | |
| Y61 | SRGQYyGGSLP | phosphoELM | |
| Y50 | LQKSQyLQLGP | PhosphoSitePlus | |
| S172 | SFSSGsQDVHQ | PhosphoSitePlus; phosphoELM; RegPhos | |
| S158 | SALHQsTMTPT | PhosphoSitePlus | |
| S86 | QTPFQsSGLDT | RegPhos | |
| S151 | WRRTNsDSALH | NuaK2 | RegPhos |
| S169 | RTNSDsALHQS | HPRD | |
| S330 | ASPTLsPLSPI | PhosphoSitePlus | |
| T161 | HQSTMtPTQPE | PhosphoSitePlus; phosphoELM | |
| S139 | GTMYLsPPADT | PhosphoSitePlus; RegPhos | |
| S333 | TLSPLsPITQA | PhosphoSitePlus | |
| S151 | WRRTNsDSALH | PhosphoSitePlus; phosphoELM | |
| S64 | QYYGGsLPNVN | PhosphoSitePlus; RegPhos | |
| S440 | GIDIAsAPALQ | RegPhos | |
| Dephosphorylation site |
| CRTC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000323332 | M297I | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CRTC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CRTC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | CRTC1_HUMAN | kinase -> substrate | RegPhos |
| CRTC1_HUMAN | S10A4_HUMAN | TF -> target gene | TRANSFAC |
| CRTC1_HUMAN | IL8_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0032793 | positive regulation of CREB transcription factor a | IEA | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0008140 | cAMP response element binding protein binding | IDA | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0051289 | protein homotetramerization | IEA | biological_process |