Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CO5_HUMAN
Description:complement component 5 [Source:HGNC Symbol;Acc:1331]
Location:chr9 q33.2
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1599KDSEItFIKKVNTRPhosphoSitePlus
T729CIKAFtECCVVANATOPhosphoSitePlus
S693AKYKHsVVKKCPhosphoSitePlus
Y1317DIDVSyKHKGAPhosphoSitePlus
Y700VKKCCyDGACVANATOPhosphoSitePlus
Y690EIAAKyKHSVVPhosphoSitePlus
S736CCVVAsQLRANPhosphoSitePlus
T971DLVPKtEIKRIPhosphoSitePlus

Dephosphorylation site
CO5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000223642Q374*COSMICHead and Neck Cancer21798893
ENSP00000223642L590FCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000223642breast ductal carcinomaMetastasistissueUp19624269
ENSP00000223642Brain CancerNormal vs. CancertissueUp2.518056677

Hyperphosphorylation site
CO5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO5_HUMANC5ARL_HUMANligand -> receptorHPMR
CO5_HUMANC5AR_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05133Pertussis
hsa05168Herpes simplex infection
hsa05322Systemic lupus erythematosus
hsa04610Complement and coagulation cascades
hsa05020Prion diseases
hsa05150Staphylococcus aureus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceIEAcellular_component
GO:0006950response to stressTASbiological_process
GO:0050921positive regulation of chemotaxisIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0031714C5a anaphylatoxin chemotactic receptor bindingIEAmolecular_function
GO:0005102receptor bindingTASmolecular_function
GO:0006957complement activation, alternative pathwayIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0033602negative regulation of dopamine secretionIEAbiological_process
GO:0005579membrane attack complexIEAcellular_component
GO:0002523leukocyte migration involved in inflammatory respoIEAbiological_process
GO:0010760negative regulation of macrophage chemotaxisIDAbiological_process
GO:0008009chemokine activityTASmolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0010575positive regulation vascular endothelial growth faIDAbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0006935chemotaxisIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0090197positive regulation of chemokine secretionIDAbiological_process
GO:0006958complement activation, classical pathwayIEAbiological_process
GO:0004866endopeptidase inhibitor activityIEAmolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006956complement activationTASbiological_process
GO:0010700negative regulation of norepinephrine secretionIEAbiological_process
GO:0019835cytolysisIEAbiological_process
GO:0006954inflammatory responseTASbiological_process


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