| UniProt/SwissProt ID: | CNN3_HUMAN |
| Description: | calponin 3, acidic [Source:HGNC Symbol;Acc:2157] |
| Location: | chr1 p21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S244 | DNSTIsLQMGT | Calponin | PhosphoSitePlus; SysPTM |
| S285 | VIHNGsQGTGT | PhosphoSitePlus | |
| Y308 | EYPDEyHGEYQ | PhosphoSitePlus | |
| Y316 | EYQDDyPRDYQ | PhosphoSitePlus | |
| S43 | EVTGMsIGPNF | CH | PhosphoSitePlus |
| S323 | RDYQYsDQGID | PhosphoSitePlus; RegPhos; SysPTM | |
| T234 | YDQKLtLQPVD | PhosphoSitePlus | |
| S162 | LKAGQsVIGLQ | PhosphoSitePlus; HPRD; SysPTM | |
| Y322 | PRDYQySDQGI | PhosphoSitePlus | |
| T184 | MTAYGtRRHLY | Calponin | PhosphoSitePlus |
| Y300 | ISDSDyQAEYP | PhosphoSitePlus | |
| T242 | PVDNStISLQM | PhosphoSitePlus | |
| S323 | RDYQYsDQGI | HPRD; phosphoELM; SysPTM | |
| S254 | TNKVAsQKGMS | Calponin | PhosphoSitePlus |
| Y10 | NKGPSyGLSAE | PhosphoSitePlus | |
| Y261 | KGMSVyGLGRQ | FYN | HPRD; RegPhos |
| S293 | TGTNGsEISDS | PhosphoSitePlus | |
| T2 | ____MtHFNKG | PhosphoSitePlus | |
| S244 | DNSTIsLQMGT | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y261 | KGMSVyGLGRQ | Calponin | PhosphoSitePlus |
| Y182 | AGMTAyGTRRH | Calponin | PhosphoSitePlus |
| Y261 | KGMSVyGLGRQ | phosphoELM | |
| T290 | SQGTGtNGSEI | HPRD | |
| S296 | NGSEIsDSDYQ | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| CNN3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CNN3_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000359225 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 11 | 18646787 | ENSP00000359225 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 14 | 18646787 | ENSP00000359225 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.36 | 19142970 |
| Hyperphosphorylation site |
| CNN3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | CNN3_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | CNN3_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| CNN3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005516 | calmodulin binding | NAS | molecular_function |
| GO:0005575 | cellular_component | ND | cellular_component |
| GO:0006939 | smooth muscle contraction | NAS | biological_process |
| GO:0014069 | postsynaptic density | IEA | cellular_component |
| GO:0030172 | troponin C binding | NAS | molecular_function |
| GO:0032780 | negative regulation of ATPase activity | IEA | biological_process |
| GO:0031032 | actomyosin structure organization | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008017 | microtubule binding | IEA | molecular_function |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0005523 | tropomyosin binding | NAS | molecular_function |