| UniProt/SwissProt ID: | CLD2_HUMAN |
| Description: | claudin 2 [Source:HGNC Symbol;Acc:2041] |
| Location: | chrX q22.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S208 | LATRSsPRPGQ | CD20; Trp_oprn_chp | PhosphoSitePlus |
| S219 | PPKVKsEFNSY | CD20; Trp_oprn_chp | PhosphoSitePlus |
| Y198 | NYYDAyQAQPL | CD20; Trp_oprn_chp | PhosphoSitePlus |
| S225 | EFNSYsLTGYV | CD20 | PhosphoSitePlus |
| Y195 | NRSNYyDAYQA | CD20; Trp_oprn_chp | PhosphoSitePlus |
| S192 | SQRNRsNYYDA | CD20; Trp_oprn_chp | PhosphoSitePlus |
| S223 | KSEFNsYSLTG | CD20 | PhosphoSitePlus |
| Y194 | RNRSNyYDAYQ | CD20; Trp_oprn_chp | PhosphoSitePlus |
| Y224 | SEFNSySLTGY | CD20 | PhosphoSitePlus |
| Dephosphorylation site |
| CLD2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000443230 | T56K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000336571 | T56K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000336571 | T56K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000441283 | T56K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000443230 | T56K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000441283 | T56K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| CLD2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| Y195 | CD20; Trp_oprn_chp | QRNRSNYyDAYQAQP | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus | Y198 | CD20; Trp_oprn_chp | RSNYYDAyQAQPLAT | cholangiocellular carcinoma | 21253578 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDX2_HUMAN | CLD2_HUMAN | TF -> target gene | TRANSFAC |
| HNF1A_HUMAN | CLD2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CLD2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042802 | identical protein binding | ISS | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005923 | tight junction | ISS | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005923 | tight junction | IEA | cellular_component |
| GO:0016338 | calcium-independent cell-cell adhesion | IEA | biological_process |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0016338 | calcium-independent cell-cell adhesion | ISS | biological_process |