Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CLD2_HUMAN
Description:claudin 2 [Source:HGNC Symbol;Acc:2041]
Location:chrX q22.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S208LATRSsPRPGQCD20; Trp_oprn_chpPhosphoSitePlus
S219PPKVKsEFNSYCD20; Trp_oprn_chpPhosphoSitePlus
Y198NYYDAyQAQPLCD20; Trp_oprn_chpPhosphoSitePlus
S225EFNSYsLTGYVCD20PhosphoSitePlus
Y195NRSNYyDAYQACD20; Trp_oprn_chpPhosphoSitePlus
S192SQRNRsNYYDACD20; Trp_oprn_chpPhosphoSitePlus
S223KSEFNsYSLTGCD20PhosphoSitePlus
Y194RNRSNyYDAYQCD20; Trp_oprn_chpPhosphoSitePlus
Y224SEFNSySLTGYCD20PhosphoSitePlus

Dephosphorylation site
CLD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000443230T56KCOSMICOvarian Cancer21720365
ENSP00000336571T56KTCGAOvarian Cancer21720365, 18772890
ENSP00000336571T56KCOSMICOvarian Cancer21720365
ENSP00000441283T56KCOSMICOvarian Cancer21720365
ENSP00000443230T56KTCGAOvarian Cancer21720365, 18772890
ENSP00000441283T56KTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
CLD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y195CD20; Trp_oprn_chpQRNRSNYyDAYQAQPcholangiocellular carcinoma21253578PhosphoSitePlus
Y198CD20; Trp_oprn_chpRSNYYDAyQAQPLATcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CDX2_HUMANCLD2_HUMANTF -> target geneTRANSFAC
HNF1A_HUMANCLD2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CLD2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042802identical protein bindingISSmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005923tight junctionISScellular_component
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005923tight junctionIEAcellular_component
GO:0016338calcium-independent cell-cell adhesionIEAbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0016338calcium-independent cell-cell adhesionISSbiological_process


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