Phosphorylation

Protein information

UniProt/SwissProt ID:	CFLAR_HUMAN
Description:	CASP8 and FADD-like apoptosis regulator [Source:HGNC Symbol;Acc:1876]
Location:	chr2 q33.1
Node attribute:	substrate; ubiquitination(target)

Position	PhosphoPeptide	Catalytic kinase	Source
Y182	GAGTSyRNVLQ		PhosphoSitePlus
Y171	TKIQKyKQSVQ	DED	PhosphoSitePlus
S314	VCVLVsRGGSQ	Peptidase_C14	PhosphoSitePlus
S273	RDTFTsLGYEV	Peptidase_C14	PhosphoSitePlus
S193	AAIQKsLKDPS		PhosphoSitePlus

CFLAR_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000411535	L293V	BIOMART	Gastric Cancer	21930507, 21930502

CFLAR_HUMAN is not differential expressed protein.

CFLAR_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
AKT1_HUMAN	CFLAR_HUMAN	kinase -> substrate	NetPath
ITCH_HUMAN	CFLAR_HUMAN	ubiquitination	NetPath

KEGG Pathway

KEGG ID	Pathway
hsa05142	Chagas disease (American trypanosomiasis)
hsa04210	Apoptosis
hsa04064	NF-kappa B signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0019048	virus-host interaction	IEA	biological_process
GO:0014732	skeletal muscle atrophy	ISS	biological_process
GO:1901740	negative regulation of myoblast fusion	ISS	biological_process
GO:0002020	protease binding	IPI	molecular_function
GO:0043085	positive regulation of catalytic activity	IDA	biological_process
GO:0014866	skeletal myofibril assembly	ISS	biological_process
GO:0008047	enzyme activator activity	IDA	molecular_function
GO:2001237	negative regulation of extrinsic apoptotic signali	IMP	biological_process
GO:0006508	proteolysis	IEA	biological_process
GO:0051092	positive regulation of NF-kappaB transcription fac	ISS	biological_process
GO:0042981	regulation of apoptotic process	IEA	biological_process
GO:0014842	regulation of satellite cell proliferation	ISS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0031264	death-inducing signaling complex	IDA	cellular_component
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB c	IEP	biological_process
GO:0006915	apoptotic process	IEA	biological_process
GO:0043403	skeletal muscle tissue regeneration	ISS	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0043066	negative regulation of apoptotic process	IMP	biological_process
GO:0008234	cysteine-type peptidase activity	IEA	molecular_function
GO:0004197	cysteine-type endopeptidase activity	IEA	molecular_function
GO:0007519	skeletal muscle tissue development	ISS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network