Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CFAH_HUMAN
Description:complement factor H [Source:HGNC Symbol;Acc:4883]
Location:chr1 q31.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T427LPKAQtTVTCMSushiPhosphoSitePlus
T150KCLPVtAPENGSushiPhosphoSitePlus
S159NGKIVsSAMEPSushiPhosphoSitePlus
S160GKIVSsAMEPDSushiPhosphoSitePlus
S451KTCSKsSIDIESushiPhosphoSitePlus
Y587RKKDQyKVGEVSushiPhosphoSitePlus
Y1008EKKDVyKAGEQSushiPhosphoSitePlus
S452TCSKSsIDIENSushiPhosphoSitePlus

Dephosphorylation site
CFAH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356399E201KCOSMICSkin Cancer21984974
ENSP00000356399W787*COSMICMelanoma21499247
ENSP00000356399G975RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000356399R582CCOSMICMelanoma21499247
ENSP00000356399Y1058HBIOMARTGastric Cancer21930507, 21930502
ENSP00000356399G350ECOSMICSkin Cancer21984974
ENSP00000356399V1060LBIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356399Brain CancerNormal vs. CancertissueUp6.818056677

Hyperphosphorylation site
CFAH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CFAH_HUMANLYAM1_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05150Staphylococcus aureus infection
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005615extracellular spaceTAScellular_component
GO:0005576extracellular regionTAScellular_component
GO:0006956complement activationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043395heparan sulfate proteoglycan bindingIDAmolecular_function
GO:0030449regulation of complement activationTASbiological_process
GO:0008201heparin bindingIDAmolecular_function
GO:0006957complement activation, alternative pathwayIEAbiological_process
GO:0045087innate immune responseTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23