| UniProt/SwissProt ID: | CFAH_HUMAN |
| Description: | complement factor H [Source:HGNC Symbol;Acc:4883] |
| Location: | chr1 q31.3 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T427 | LPKAQtTVTCM | Sushi | PhosphoSitePlus |
| T150 | KCLPVtAPENG | Sushi | PhosphoSitePlus |
| S159 | NGKIVsSAMEP | Sushi | PhosphoSitePlus |
| S160 | GKIVSsAMEPD | Sushi | PhosphoSitePlus |
| S451 | KTCSKsSIDIE | Sushi | PhosphoSitePlus |
| Y587 | RKKDQyKVGEV | Sushi | PhosphoSitePlus |
| Y1008 | EKKDVyKAGEQ | Sushi | PhosphoSitePlus |
| S452 | TCSKSsIDIEN | Sushi | PhosphoSitePlus |
| Dephosphorylation site |
| CFAH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356399 | E201K | COSMIC | Skin Cancer | 21984974 | ENSP00000356399 | W787* | COSMIC | Melanoma | 21499247 | ENSP00000356399 | G975R | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000356399 | R582C | COSMIC | Melanoma | 21499247 | ENSP00000356399 | Y1058H | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000356399 | G350E | COSMIC | Skin Cancer | 21984974 | ENSP00000356399 | V1060L | BIOMART | Gastric Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356399 | Brain Cancer | Normal vs. Cancer | tissue | Up | 6.8 | 18056677 |
| Hyperphosphorylation site |
| CFAH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CFAH_HUMAN | LYAM1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05150 | Staphylococcus aureus infection |
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0006956 | complement activation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043395 | heparan sulfate proteoglycan binding | IDA | molecular_function |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0008201 | heparin binding | IDA | molecular_function |
| GO:0006957 | complement activation, alternative pathway | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |