| UniProt/SwissProt ID: | CDC23_HUMAN |
| Description: | cell division cycle 23 [Source:HGNC Symbol;Acc:1724] |
| Location: | chr5 q31.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T559 | GETPTtEVPAP | CDC2(CDK1 | RegPhos |
| Y267 | QIAVAyHNIRD | phosphoELM; RegPhos | |
| S530 | LWDEAsTCAQK | DUF772; TPR_2 | PhosphoSitePlus |
| S223 | MLKFLsLPDTW | PhosphoSitePlus | |
| S593 | SPLNLsSVTP_ | PhosphoSitePlus | |
| S587 | SPLNLsSV | phosphoELM | |
| S594 | PLNLSsVTP__ | PhosphoSitePlus | |
| S576 | FFLPAsLSANN | PhosphoSitePlus; HPRD | |
| S593 | SPLNLsSV | HPRD | |
| T596 | NLSSVtP____ | PhosphoSitePlus | |
| Y273 | QIAVAyHNIRD | PhosphoSitePlus | |
| T559 | GETPTtEVPAP | PLK1 | RegPhos |
| S594 | PLNLSsV | HPRD | |
| S304 | NMDTFsNLLYV | HPRD | |
| Y460 | CYWRAyAVGDV | PhosphoSitePlus | |
| Y308 | FSNLLyVRSMK | HPRD | |
| S587 | SPLNLsSVTP | RegPhos | |
| Y341 | VIGNYySLRSQ | TPR_1 | PhosphoSitePlus |
| T584 | ANNTPtRRVSP | PhosphoSitePlus; HPRD | |
| S588 | PLNLSsVTP | RegPhos | |
| T556 | RNQGEtPTTEV | CDC2(CDK1 | RegPhos |
| T576 | LSANNtPTRRV | CDK1 | phosphoELM |
| T558 | QGETPtTEVPA | phosphoELM | |
| T43 | LIAGLtRERGL | APC8 | PhosphoSitePlus |
| T559 | GETPTtEVPAP | phosphoELM; RegPhos | |
| T556 | RNQGEtPTTEV | CDK1 | phosphoELM |
| S588 | PTRRVsPLNLS | PhosphoSitePlus; HPRD | |
| T576 | LSANNtPTRRV | CDC2(CDK1 | RegPhos |
| T556 | RNQGEtPTTEV | phosphoELM; RegPhos | |
| T565 | GETPTtEVPAP | PhosphoSitePlus; HPRD | |
| Y353 | EKAALyFQRAL | TPR_1 | PhosphoSitePlus |
| T596 | NLSSV | HPRD | |
| S578 | LPASLsANNTP | PhosphoSitePlus; HPRD | |
| Y340 | CVIGNyYSLRS | TPR_1 | PhosphoSitePlus |
| Y115 | NSKKAyFLYMY | APC8; Apc3 | PhosphoSitePlus |
| Y120 | YFLYMySRYLS | APC8; Apc3 | PhosphoSitePlus |
| S572 | LPASLsANNTP | phosphoELM; RegPhos | |
| T542 | CAFNDtREEGK | PhosphoSitePlus | |
| S582 | PTRRVsPLNLS | phosphoELM; RegPhos; SysPTM | |
| T590 | NLSSV | phosphoELM | |
| T576 | LSANNtPTRRV | phosphoELM | |
| T582 | LSANNtPTRRV | PhosphoSitePlus; HPRD | |
| S284 | IDKALsIFNEL | PhosphoSitePlus | |
| Y329 | CEIDKyRVETC | PhosphoSitePlus | |
| S588 | PLNLSsV | phosphoELM | |
| T578 | ANNTPtRRVSP | phosphoELM | |
| T562 | RNQGEtPTTEV | PhosphoSitePlus; HPRD | |
| T564 | QGETPtTEVPA | PhosphoSitePlus; HPRD | |
| T590 | NLSSVtP | RegPhos | |
| S121 | FLYMYsRYLSG | APC8; Apc3 | PhosphoSitePlus |
| S570 | FFLPAsLSANN | phosphoELM | |
| T556 | RNQGEtPTTEV | PLK1 | phosphoELM; RegPhos |
| Dephosphorylation site |
| CDC23_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CDC23_HUMAN do not have mutation site. |
| Differential expressed protein |
| CDC23_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDC23_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PLK1_HUMAN | CDC23_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | CDC23_HUMAN | kinase -> substrate | RegPhos |
| CDK1_HUMAN | CDC23_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| hsa05166 | HTLV-I infection |
| hsa04114 | Oocyte meiosis |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007091 | mitotic metaphase/anaphase transition | TAS | biological_process |
| GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0007049 | cell cycle | TAS | biological_process |
| GO:0030071 | regulation of mitotic metaphase/anaphase transitio | IDA | biological_process |
| GO:0007080 | mitotic metaphase plate congression | IDA | biological_process |
| GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
| GO:0000080 | G1 phase of mitotic cell cycle | IDA | biological_process |
| GO:0007096 | regulation of exit from mitosis | TAS | biological_process |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004842 | ubiquitin-protein ligase activity | TAS | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0007067 | mitosis | IDA | biological_process |
| GO:0070979 | protein K11-linked ubiquitination | IDA | biological_process |
| GO:0005680 | anaphase-promoting complex | IDA | cellular_component |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | TAS | biological_process |