| UniProt/SwissProt ID: | CD40L_HUMAN |
| Description: | CD40 ligand [Source:HGNC Symbol;Acc:11935] |
| Location: | chrX q26.3 |
| Node attribute: | PPI(source); PPI(target); ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y5 | _MIETyNQTSP | PhosphoSitePlus | |
| T4 | __MIEtYNQTS | PhosphoSitePlus | |
| Dephosphorylation site |
| CD40L_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359663 | R11Q | COSMIC | Melanoma | |
| Differential expressed protein |
| CD40L_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD40L_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CD40L_HUMAN | TNR5_HUMAN | ligand -> receptor | HPMR |
| ICOS_HUMAN | CD40L_HUMAN | other | KEGG |
| CD40L_HUMAN | TNR5_HUMAN | other | KEGG |
| AKNA_HUMAN | CD40L_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04660 | T cell receptor signaling pathway |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04064 | NF-kappa B signaling pathway |
| hsa05330 | Allograft rejection |
| hsa05416 | Viral myocarditis |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05322 | Systemic lupus erythematosus |
| hsa05145 | Toxoplasmosis |
| hsa05340 | Primary immunodeficiency |
| hsa05320 | Autoimmune thyroid disease |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05144 | Malaria |
| hsa05310 | Asthma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048305 | immunoglobulin secretion | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0005174 | CD40 receptor binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0045190 | isotype switching | ISS | biological_process |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0051023 | regulation of immunoglobulin secretion | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:2000353 | positive regulation of endothelial cell apoptotic | IDA | biological_process |
| GO:0045190 | isotype switching | IEA | biological_process |
| GO:0005125 | cytokine activity | IEA | molecular_function |
| GO:0007159 | leukocyte cell-cell adhesion | NAS | biological_process |
| GO:0030168 | platelet activation | IDA | biological_process |
| GO:0032735 | positive regulation of interleukin-12 production | IDA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0042100 | B cell proliferation | IDA | biological_process |
| GO:0005164 | tumor necrosis factor receptor binding | IEA | molecular_function |
| GO:0006954 | inflammatory response | IDA | biological_process |
| GO:0030183 | B cell differentiation | IEA | biological_process |