Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD40L_HUMAN
Description:CD40 ligand [Source:HGNC Symbol;Acc:11935]
Location:chrX q26.3
Node attribute:PPI(source); PPI(target); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y5_MIETyNQTSPPhosphoSitePlus
T4__MIEtYNQTSPhosphoSitePlus

Dephosphorylation site
CD40L_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359663R11QCOSMICMelanoma

Differential expressed protein
CD40L_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD40L_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CD40L_HUMANTNR5_HUMANligand -> receptorHPMR
ICOS_HUMANCD40L_HUMANotherKEGG
CD40L_HUMANTNR5_HUMANotherKEGG
AKNA_HUMANCD40L_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa04064NF-kappa B signaling pathway
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04514Cell adhesion molecules (CAMs)
hsa05322Systemic lupus erythematosus
hsa05145Toxoplasmosis
hsa05340Primary immunodeficiency
hsa05320Autoimmune thyroid disease
hsa04060Cytokine-cytokine receptor interaction
hsa05144Malaria
hsa05310Asthma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048305immunoglobulin secretionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0006955immune responseIEAbiological_process
GO:0005174CD40 receptor bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0050776regulation of immune responseTASbiological_process
GO:0045190isotype switchingISSbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0051023regulation of immunoglobulin secretionIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:2000353positive regulation of endothelial cell apoptotic IDAbiological_process
GO:0045190isotype switchingIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0007159leukocyte cell-cell adhesionNASbiological_process
GO:0030168platelet activationIDAbiological_process
GO:0032735positive regulation of interleukin-12 productionIDAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0042100B cell proliferationIDAbiological_process
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0006954inflammatory responseIDAbiological_process
GO:0030183B cell differentiationIEAbiological_process


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