Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCNE1_HUMAN
Description:cyclin E1 [Source:HGNC Symbol;Acc:1589]
Location:chr19 q12
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T395PSGLLtPPQSGCDK2phosphoELM; RegPhos; SysPTM
T395PSGLLtPPQSGGSK3A(GSK3 alphaRegPhos; SysPTM
S391ASPLPsGLLTPHPRD; phosphoELM
S100RIIAPsRGSPLHPRD
S399LTPPQsGKKQSCDK2HPRD; phosphoELM; RegPhos
T395PSGLLtPPQSGGSK_groupRegPhos; SysPTM
T395PSGLLtPPQSGGSK3B(GSK3 betaRegPhos; SysPTM
S73CADPCsLIPTPPhosphoSitePlus
S387EQNRAsPLPSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T395PSGLLtPPQSGGSK-3_alphaphosphoELM; SysPTM
S103APSRGsPLPVLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T77CSLIPtPDKEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S381KKAMLsEQNRAPhosphoSitePlus; HPRD
T395PSGLLtPPQSGGSK-3_betaphosphoELM; SysPTM
S90RVYPNsTCKPRPhosphoSitePlus
T395PSGLLtPPQSGGSK3BHPRD; RegPhos; SysPTM
S399LTPPQsGKKQSPhosphoSitePlus
T395PSGLLtPPQSGPhosphoSitePlus; phosphoELM; SysPTM
S59RDQCGsQPWDNPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
CCNE1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262643T362ACOSMICLung Cancer20668451
ENSP00000262643R95WDing2008, COSMICLung Cancer18948947

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262643Breast CancerNormal vs. CancertissueUp6.516470630

Hyperphosphorylation site
CCNE1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANCCNE1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3A_HUMANCCNE1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CCNE1_HUMANCABL1_HUMANkinase -> substrateHPRD
CDK2_HUMANCCNE1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANCCNE1_HUMANkinase -> substrateRegPhos
E2F1_HUMANCCNE1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa05222Small cell lung cancer
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05203Viral carcinogenesis
hsa05215Prostate cancer
hsa05162Measles
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003713transcription coactivator activityNASmolecular_function
GO:0006468protein phosphorylationIMPbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0000307cyclin-dependent protein kinase holoenzyme complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0051301cell divisionIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0006270DNA replication initiationIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0016538cyclin-dependent protein kinase regulator activityIEAmolecular_function
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0005634nucleusNAScellular_component
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process


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