Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCND2_HUMAN
Description:cyclin D2 [Source:HGNC Symbol;Acc:1583]
Location:chr12 p13.32
Node attribute:kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S271RDGSKsEDELDCyclin_CPhosphoSitePlus
S279ELDQAsTPTDVCyclin_CPhosphoSitePlus
S269DQRDGsKSEDECyclin_CPhosphoSitePlus
T282QASTPtDVRDIPhosphoSitePlus
T280LDQAStPTDVRCyclin_CPhosphoSitePlus

Dephosphorylation site
CCND2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261254P281RCOSMICLymphoma21642962
ENSP00000261254I131MCOSMICBreast Cancer20668451
ENSP00000261254R262LCOSMICRenal Cancer20054297

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261254hepatitis C virusNormal vs. Cancercell lineDown17928924
ENSP00000261254Lung CancerNormal vs. CancertissueUp12943690
ENSP00000261254Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
CCND2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCND2_HUMANRB_HUMANkinase -> substrateHPRD
GLI1_HUMANCCND2_HUMANTF -> target geneTRANSFAC
SP1_HUMANCCND2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa05162Measles
hsa05202Transcriptional misregulation in cancer
hsa05203Viral carcinogenesis
hsa04310Wnt signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04510Focal adhesion
hsa05166HTLV-I infection
hsa04115p53 signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0000785chromatinIDAcellular_component
GO:0051726regulation of cell cycleIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0045737positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0000307cyclin-dependent protein kinase holoenzyme complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0000079regulation of cyclin-dependent protein kinase actiIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0005829cytosolIDAcellular_component


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23