Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CATD_HUMAN
Description:cathepsin D [Source:HGNC Symbol;Acc:2529]
Location:chr11 p15.5
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y354LSPEDyTLKVSAspPhosphoSitePlus
Y325LIQGEyMIPCEAspPhosphoSitePlus
S252LGGTDsKYYKGHPRD
Y347LGGKGyKLSPEAspPhosphoSitePlus

Dephosphorylation site
CATD_HUMAN do not have dephosphorylation site.

Mutation site
CATD_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000236671hepatitis C virusNormal vs. CancertissueDown0.218715028
ENSP00000236671Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.918646787
ENSP00000236671Breast CancerMetastasiscell lineUp16637015
ENSP00000236671Pancreatic CancerNormal vs. CancertissueUp6.716215274
ENSP00000236671colorectal cancerNormal vs. CancertissueUp1.714997500
ENSP00000236671colorectal cancerNormal vs. CancertissueDown0.7115924290
ENSP00000236671Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineDown0.0414557597
ENSP00000236671Breast CancerMetastasiscell lineUp16637015
ENSP00000236671MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.3517854218
ENSP00000236671MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp2.517854218
ENSP00000236671Breast CancerMetastasistissueDown18257521
ENSP00000236671hepatitis C virusNormal vs. CancertissueDown0.1916097030
ENSP00000236671Hepatocellular CarcinomaNormal vs. Cancercell lineUp17214954
ENSP00000236671Hepatocellular CarcinomaMetastasiscell lineUp17214954
ENSP00000236671Hepatocellular CarcinomaMetastasiscell lineUp17214954
ENSP00000236671hepatitis B virusTreatment (none vs tetracycline-treatment)cell lineUp2.119671925
ENSP00000236671Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000236671Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineUp15684709
ENSP00000236671Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000236671Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.320804217
ENSP00000236671Breast CancerMetastasiscell lineUp1.318582095
ENSP00000236671Breast CancerNormal vs. CancertissueUp220005186
ENSP00000236671Breast CancerNormal vs. Cancercell lineUp5.220052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineUp7.820052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineUp8.420052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineUp9.920052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineDown0.1120052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineDown0.1920052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineDown0.4820052998
ENSP00000236671Breast CancerNormal vs. Cancercell lineDown0.6820052998
ENSP00000236671Breast CancerMetastasiscell lineDown0.01120052998
ENSP00000236671Breast CancerMetastasiscell lineDown0.01920052998
ENSP00000236671Breast CancerMetastasiscell lineDown0.02520052998
ENSP00000236671Breast CancerMetastasiscell lineDown0.05620052998
ENSP00000236671Breast CancerNormal vs. CancertissueUp1.820087651
ENSP00000236671Breast CancerNormal vs. CancertissueUp0.4620739354
ENSP00000236671Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp2.116807943
ENSP00000236671Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineUp1120858016
ENSP00000236671Pancreatic CancerNormal vs. CancertissueUp<215526344
ENSP00000236671Pancreatic CancerNormal vs. CancertissueUp3.416230073
ENSP00000236671Hepatocellular CarcinomaNormal vs. CancertissueUp2.619658107

Hyperphosphorylation site
CATD_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANCATD_HUMANTF -> target geneTRANSFAC
ESR1_HUMANCATD_HUMANTF -> target geneTRANSFAC
ESR2_HUMANCATD_HUMANTF -> target geneTRANSFAC
USF1_HUMANCATD_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
CATD_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005764lysosomeIEAcellular_component
GO:0043202lysosomal lumenTAScellular_component
GO:0031012extracellular matrixIDAcellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0008219cell deathIEAbiological_process
GO:0000045autophagic vacuole assemblyIEAbiological_process
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0008233peptidase activityIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0004190aspartic-type endopeptidase activityIEAmolecular_function


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