| UniProt/SwissProt ID: | C4BPA_HUMAN |
| Description: | complement component 4 binding protein, alpha [Source:HGNC Symbol;Acc:1325] |
| Location: | chr1 q32.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S474 | SYSHWsAPAPQ | Sushi | PhosphoSitePlus |
| Y470 | KLSCSySHWSA | Sushi | PhosphoSitePlus |
| S471 | LSCSYsHWSAP | Sushi | PhosphoSitePlus |
| S469 | AKLSCsYSHWS | Sushi | PhosphoSitePlus |
| S495 | VNGRLsVDKDQ | Sushi | PhosphoSitePlus |
| Dephosphorylation site |
| C4BPA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356037 | S208P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000356037 | S208P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356037 | E534V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000356037 | Y515* | COSMIC | Intestines Cancer | 16959974 | ENSP00000356037 | Y515X | BIOMART | Colorectal Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000356037 | Lung Cancer | Normal vs. Cancer | tissue | Up | 2.5 | 17705522 | ENSP00000356037 | Brain Cancer | Normal vs. Cancer | tissue | Up | 3.8 | 18056677 |
| Hyperphosphorylation site |
| C4BPA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FOXJ2_HUMAN | C4BPA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| C4BPA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006958 | complement activation, classical pathway | IEA | biological_process |