Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:C4BPA_HUMAN
Description:complement component 4 binding protein, alpha [Source:HGNC Symbol;Acc:1325]
Location:chr1 q32.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S474SYSHWsAPAPQSushiPhosphoSitePlus
Y470KLSCSySHWSASushiPhosphoSitePlus
S471LSCSYsHWSAPSushiPhosphoSitePlus
S469AKLSCsYSHWSSushiPhosphoSitePlus
S495VNGRLsVDKDQSushiPhosphoSitePlus

Dephosphorylation site
C4BPA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356037S208PTCGAOvarian Cancer21720365, 18772890
ENSP00000356037S208PCOSMICOvarian Cancer21720365
ENSP00000356037E534VCOSMICOvarian Cancer21720365
ENSP00000356037Y515*COSMICIntestines Cancer16959974
ENSP00000356037Y515XBIOMARTColorectal Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356037Lung CancerNormal vs. CancertissueUp2.517705522
ENSP00000356037Brain CancerNormal vs. CancertissueUp3.818056677

Hyperphosphorylation site
C4BPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FOXJ2_HUMANC4BPA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
C4BPA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0045087innate immune responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0030449regulation of complement activationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006958complement activation, classical pathwayIEAbiological_process


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