| UniProt/SwissProt ID: | C163A_HUMAN |
| Description: | CD163 molecule [Source:HGNC Symbol;Acc:1631] |
| Location: | chr12 p13.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1084 | QRLAVsSRGEN | PKCa | RegPhos |
| S1085 | RLAVSsRGENL | P67870(Casein kinase II ) | RegPhos |
| S1084 | QRLAVsSRGEN | PRKCA | HPRD |
| S14 | LEDSGsADFRR | RegPhos | |
| T1072 | ALFFLtKKRRQ | PRKCA | HPRD |
| S1084 | QRLAVsSRGEN | PhosphoSitePlus | |
| S1085 | RLAVSsRGENL | CSNK2B | HPRD |
| T1072 | ALFFLtKKRRQ | PKCa | RegPhos |
| Dephosphorylation site |
| C163A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000352071 | K640E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | P310L | COSMIC | Melanoma | 20016485 | ENSP00000403885 | A963S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000352071 | Q241H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | G873E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | A84G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | L1057V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | G1014D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000352071 | A963S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000352071 | I1137N | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000352071 | Gastric Cancer | Metastasis | cell line | Up | 2.2 | 17022644 | ENSP00000352071 | Gastric Cancer | Metastasis | cell line | Up | 2.2 | 17022644 | ENSP00000352071 | Ovarian Cancer | Treatment (chemotherapy-sensitive vs. chemotherapy-resistant) | tissue | Up | 2 | 19422301 |
| Hyperphosphorylation site |
| C163A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK2B_HUMAN | C163A_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | C163A_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | C163A_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| C163A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006953 | acute-phase response | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005044 | scavenger receptor activity | NAS | molecular_function |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |