Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BKRB1_HUMAN
Description:bradykinin receptor B1 [Source:HGNC Symbol;Acc:1029]
Location:chr14 q32.2
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S334QCTPKsLAPISPhosphoSitePlus
S339SLAPIsSSHRKPhosphoSitePlus; HPRD
S340LAPISsSHRKEPhosphoSitePlus

Dephosphorylation site
BKRB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216629L226MTCGAOvarian Cancer21720365, 18772890
ENSP00000216629F49SCOSMICOvarian Cancer21720365
ENSP00000216629H199NTCGAOvarian Cancer21720365, 18772890
ENSP00000216629A250VTCGAOvarian Cancer21720365, 18772890
ENSP00000216629H199NCOSMICOvarian Cancer21720365
ENSP00000216629L226MCOSMICOvarian Cancer21720365
ENSP00000216629F101IBIOMARTBreast Cancer21930507, 21930502
ENSP00000216629A250VCOSMICOvarian Cancer21720365

Differential expressed protein
BKRB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BKRB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KNG1_HUMANBKRB1_HUMANligand -> receptorHPMR
BKRB1_HUMANGNAQ_HUMANGPCR -> GproteingpDB
BKRB1_HUMANGNA11_HUMANGPCR -> GproteingpDB
IP3KA_HUMANBKRB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04080Neuroactive ligand-receptor interaction
hsa04610Complement and coagulation cascades
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042277peptide bindingIEAmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0030308negative regulation of cell growthIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0019233sensory perception of painIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0016477cell migrationIEAbiological_process
GO:0051281positive regulation of release of sequestered calcIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0005783endoplasmic reticulumTAScellular_component
GO:0004947bradykinin receptor activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0002687positive regulation of leukocyte migrationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process


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