| UniProt/SwissProt ID: | BACE1_HUMAN |
| Description: | beta-site APP-cleaving enzyme 1 [Source:HGNC Symbol;Acc:933] |
| Location: | chr11 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y260 | RREWYyEVIIV | Asp | PhosphoSitePlus |
| S429 | FADDIsL | CSNK1D | HPRD |
| S498 | FADDIsLLK__ | PhosphoSitePlus | |
| S473 | FADDIsL | CSNK1D | HPRD |
| S498 | FADDIsLLK | CK1d | RegPhos |
| S498 | FADDIsL | CK1_alpha | phosphoELM |
| S498 | FADDIsL | CK1_delta | phosphoELM |
| S498 | FADDIsLLK | CK1d(CK1 delta | RegPhos |
| S498 | FADDIsLLK | CK1a(CK1 alpha | RegPhos |
| S498 | FADDIsL | CSNK1D | HPRD |
| S71 | NLRGKsGQGYY | PhosphoSitePlus | |
| S454 | FADDIsL | CSNK1D | HPRD |
| S308 | EAAVKsIKAAS | Asp | PhosphoSitePlus |
| Dephosphorylation site |
| BACE1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318585 | F60L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318585 | A419G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000424536 | R189M | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000318585 | R189M | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| BACE1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BACE1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1A_HUMAN | BACE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1D_HUMAN | BACE1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05010 | Alzheimer's disease |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004190 | aspartic-type endopeptidase activity | IDA | molecular_function |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0008798 | beta-aspartyl-peptidase activity | TAS | molecular_function |
| GO:0005802 | trans-Golgi network | IDA | cellular_component |
| GO:0030659 | cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0006509 | membrane protein ectodomain proteolysis | TAS | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0050435 | beta-amyloid metabolic process | IDA | biological_process |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | IDA | cellular_component |
| GO:0006508 | proteolysis | IDA | biological_process |
| GO:0005768 | endosome | IDA | cellular_component |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0016021 | integral to membrane | NAS | cellular_component |