Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AT2A2_HUMAN
Description:ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [Source:HGNC Symbol;Acc:812]
Location:chr12 q24.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S721GIAMGsGTAVAHydrolasePhosphoSitePlus
Y867PRVSFyQLSHFCation_ATPase_CPhosphoSitePlus
Y497KSMSVyCTPNKHydrolasePhosphoSitePlus
S178LRVDQsILTGEHPRD
S730VAKTAsEMVLAPhosphoSitePlus
S495DRKSMsVYCTPHydrolasePhosphoSitePlus
T741DDNFStIVAAVPhosphoSitePlus
S38KERWGsNELPACaMK2_groupRegPhos
Y836WLFFRyLAIGCCation_ATPase_C; TMPhosphoSitePlus
S546KQKIMsVIREWHydrolasePhosphoSitePlus
T624RVIMItGDNKGHydrolasePhosphoSitePlus
S38KERWGsNELPACAMK2AHPRD
Y427DSALDyNEAKGHydrolasePhosphoSitePlus
S973MVLKIsLPVILCation_ATPase_C; TMPhosphoSitePlus
S38KERWGsNELPACaM-KII_groupphosphoELM
T723AMGSGtAVAKTHydrolasePhosphoSitePlus
T226GVVVAtGVNTEE1-E2_ATPasePhosphoSitePlus
S261FGEQLsKVISLE1-E2_ATPase; TMPhosphoSitePlus
S184ILTGEsVSVIKHPRD
T499MSVYCtPNKPSHydrolasePhosphoSitePlus
S504TPNKPsRTSMSHydrolasePhosphoSitePlus
T484MKKEFtLEFSRHydrolasePhosphoSitePlus
S663DELNPsAQRDAHPRD; phosphoELM; RegPhos
T230ATGVNtEIGKIE1-E2_ATPasePhosphoSitePlus
T537TKVPMtSGVKQRegPhos
Y122EALKEyEPEMGE1-E2_ATPasePhosphoSitePlus
S538KVPMTsGVKQKHydrolasePhosphoSitePlus
S38KERWGsNELPACaMK2aRegPhos
S663DELNPsAQRDAHydrolasePhosphoSitePlus

Dephosphorylation site
AT2A2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311186L485VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000311186I774VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000311186S178LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000311186S609YTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378872Gastric CancerMetastasiscell lineDown0.6417022644
ENSP00000378872Gastric CancerMetastasiscell lineDown0.6417022644

Hyperphosphorylation site
AT2A2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANAT2A2_HUMANkinase -> substrateRegPhos
KCC4_HUMANAT2A2_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANAT2A2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05414Dilated cardiomyopathy
hsa05010Alzheimer's disease
hsa04972Pancreatic secretion
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa04260Cardiac muscle contraction
hsa04020Calcium signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0031095platelet dense tubular network membraneTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0006984ER-nucleus signaling pathwayIEAbiological_process
GO:0016529sarcoplasmic reticulumIDAcellular_component
GO:0005388calcium-transporting ATPase activityIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0007155cell adhesionTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0044548S100 protein bindingIPImolecular_function
GO:0019829cation-transporting ATPase activityIEAmolecular_function
GO:0006816calcium ion transportIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006754ATP biosynthetic processIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0043231intracellular membrane-bounded organelleTAScellular_component
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0008544epidermis developmentTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0033017sarcoplasmic reticulum membraneTAScellular_component
GO:0006812cation transportIEAbiological_process
GO:0016020membraneTAScellular_component
GO:0070296sarcoplasmic reticulum calcium ion transportTASbiological_process
GO:0006810transportTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0034220ion transmembrane transportTASbiological_process
GO:0005789endoplasmic reticulum membraneIDAcellular_component
GO:0045822negative regulation of heart contractionIEAbiological_process


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