| UniProt/SwissProt ID: | AT2A2_HUMAN |
| Description: | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [Source:HGNC Symbol;Acc:812] |
| Location: | chr12 q24.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S721 | GIAMGsGTAVA | Hydrolase | PhosphoSitePlus |
| Y867 | PRVSFyQLSHF | Cation_ATPase_C | PhosphoSitePlus |
| Y497 | KSMSVyCTPNK | Hydrolase | PhosphoSitePlus |
| S178 | LRVDQsILTGE | HPRD | |
| S730 | VAKTAsEMVLA | PhosphoSitePlus | |
| S495 | DRKSMsVYCTP | Hydrolase | PhosphoSitePlus |
| T741 | DDNFStIVAAV | PhosphoSitePlus | |
| S38 | KERWGsNELPA | CaMK2_group | RegPhos |
| Y836 | WLFFRyLAIGC | Cation_ATPase_C; TM | PhosphoSitePlus |
| S546 | KQKIMsVIREW | Hydrolase | PhosphoSitePlus |
| T624 | RVIMItGDNKG | Hydrolase | PhosphoSitePlus |
| S38 | KERWGsNELPA | CAMK2A | HPRD |
| Y427 | DSALDyNEAKG | Hydrolase | PhosphoSitePlus |
| S973 | MVLKIsLPVIL | Cation_ATPase_C; TM | PhosphoSitePlus |
| S38 | KERWGsNELPA | CaM-KII_group | phosphoELM |
| T723 | AMGSGtAVAKT | Hydrolase | PhosphoSitePlus |
| T226 | GVVVAtGVNTE | E1-E2_ATPase | PhosphoSitePlus |
| S261 | FGEQLsKVISL | E1-E2_ATPase; TM | PhosphoSitePlus |
| S184 | ILTGEsVSVIK | HPRD | |
| T499 | MSVYCtPNKPS | Hydrolase | PhosphoSitePlus |
| S504 | TPNKPsRTSMS | Hydrolase | PhosphoSitePlus |
| T484 | MKKEFtLEFSR | Hydrolase | PhosphoSitePlus |
| S663 | DELNPsAQRDA | HPRD; phosphoELM; RegPhos | |
| T230 | ATGVNtEIGKI | E1-E2_ATPase | PhosphoSitePlus |
| T537 | TKVPMtSGVKQ | RegPhos | |
| Y122 | EALKEyEPEMG | E1-E2_ATPase | PhosphoSitePlus |
| S538 | KVPMTsGVKQK | Hydrolase | PhosphoSitePlus |
| S38 | KERWGsNELPA | CaMK2a | RegPhos |
| S663 | DELNPsAQRDA | Hydrolase | PhosphoSitePlus |
| Dephosphorylation site |
| AT2A2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000311186 | L485V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000311186 | I774V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000311186 | S178L | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000311186 | S609Y | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000378872 | Gastric Cancer | Metastasis | cell line | Down | 0.64 | 17022644 | ENSP00000378872 | Gastric Cancer | Metastasis | cell line | Down | 0.64 | 17022644 |
| Hyperphosphorylation site |
| AT2A2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | AT2A2_HUMAN | kinase -> substrate | RegPhos |
| KCC4_HUMAN | AT2A2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC2A_HUMAN | AT2A2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05414 | Dilated cardiomyopathy |
| hsa05010 | Alzheimer's disease |
| hsa04972 | Pancreatic secretion |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (A |
| hsa04260 | Cardiac muscle contraction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0031095 | platelet dense tubular network membrane | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0006984 | ER-nucleus signaling pathway | IEA | biological_process |
| GO:0016529 | sarcoplasmic reticulum | IDA | cellular_component |
| GO:0005388 | calcium-transporting ATPase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0019829 | cation-transporting ATPase activity | IEA | molecular_function |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006754 | ATP biosynthetic process | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0002026 | regulation of the force of heart contraction | IEA | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | TAS | cellular_component |
| GO:0006874 | cellular calcium ion homeostasis | IEA | biological_process |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0033017 | sarcoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006812 | cation transport | IEA | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0070296 | sarcoplasmic reticulum calcium ion transport | TAS | biological_process |
| GO:0006810 | transport | TAS | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0034220 | ion transmembrane transport | TAS | biological_process |
| GO:0005789 | endoplasmic reticulum membrane | IDA | cellular_component |
| GO:0045822 | negative regulation of heart contraction | IEA | biological_process |