Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ASSY_HUMAN
Description:argininosuccinate synthase 1 [Source:HGNC Symbol;Acc:758]
Location:chr9 q34.11
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y87LYEDRyLLGTSHPRD
S352GKVQVsVLKGQArginosuc_synthPhosphoSitePlus
S131VRFELsCYSLAArginosuc_synthPhosphoSitePlus
Y163NDLMEyAKQHGArginosuc_synthPhosphoSitePlus
S92YLLGTsLARPCArginosuc_synthPhosphoSitePlus
Y383NVQGDyEPTDAArginosuc_synthPhosphoSitePlus
T174IPIPVtPKNPWArginosuc_synthPhosphoSitePlus
S180PKNPWsMDENLArginosuc_synthPhosphoSitePlus
T219AKAPNtPDILEHPRD
T91RYLLGtSLARPHPRD
Y133FELSCySLAPQArginosuc_synthPhosphoSitePlus
Y322FAELVyTGFWHArginosuc_synthPhosphoSitePlus
Y83QSSALyEDRYLArginosuc_synthPhosphoSitePlus
S180PKNPWsMDENLHPRD
Y87LYEDRyLLGTSArginosuc_synthPhosphoSitePlus
Y359LKGQVyILGREArginosuc_synthPhosphoSitePlus
T219AKAPNtPDILEArginosuc_synthPhosphoSitePlus
T174IPIPVtPKNPWHPRD
Y113REGAKyVSHGAArginosuc_synthPhosphoSitePlus
S92YLLGTsLARPCHPRD
Y282KSRGIyETPAGHPRD
S134ELSCYsLAPQIArginosuc_synthPhosphoSitePlus
Y291AGTILyHAHLDArginosuc_synthPhosphoSitePlus

Dephosphorylation site
ASSY_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361469K412TCOSMICOvarian Cancer21720365
ENSP00000361471K412TTCGAOvarian Cancer21720365, 18772890
ENSP00000361469K412TTCGAOvarian Cancer21720365, 18772890
ENSP00000361470K412TTCGAOvarian Cancer21720365, 18772890
ENSP00000253004K412TTCGAOvarian Cancer21720365, 18772890
ENSP00000361469T210ICOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000361470hepatitis C virusNormal vs. CancertissueDown0.218715028
ENSP00000361470hepatitis B virusNormal vs. CancertissueDown0.2714726492
ENSP00000361470hepatitis B virusNormal vs. CancertissueDown0.08814654528
ENSP00000361470hepatitis C virusNormal vs. CancertissueDown0.08814654528
ENSP00000361470Hepatocellular CarcinomaNormal vs. CancertissueDown0.08814654528
ENSP00000361470Hepatocellular CarcinomaNormal vs. CancertissueDown18571811
ENSP00000361470Hepatocellular CarcinomaNormal vs. CancertissueDown0.519956837
ENSP00000361470Breast CancerNormal vs. Cancercell lineUp4.920198662
ENSP00000361470Breast CancerMetastasiscell lineUp2.220198662
ENSP00000361470Renal CancerNormal vs. CancertissueDown0.4312923786
ENSP00000361470Renal CancerNormal vs. CancertissueDown19164279
ENSP00000361470Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.720625496

Hyperphosphorylation site
ASSY_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANASSY_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ASSY_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006526arginine biosynthetic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0000050urea cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0004055argininosuccinate synthase activityIEAmolecular_function
GO:0005737cytoplasmTAScellular_component


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